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Interferon epsilon as a novel anti-viral agent in the testis [human]

ABSTRACT: Interferon epsilon as a novel anti-viral agent in the testis [human]

PROVIDER: PRJNA1063600 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27493626.fastq.gz	Fastqsanger.gz
	SRR27493627.fastq.gz	Fastqsanger.gz
	SRR27493628.fastq.gz	Fastqsanger.gz
	SRR27493629.fastq.gz	Fastqsanger.gz
	SRR27493630.fastq.gz	Fastqsanger.gz

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Interferon epsilon as a novel anti-viral agent in the testis

Project description:Interferon epsilon as a novel anti-viral agent in the testis

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Interferon epsilon as a novel anti-viral agent in the testis [human]

Project description:The testis is susceptible to viral infections, which can impair fertility. Spermatogenic cells were thought to lack anti-viral defences, including interferon (IFN) or IFN-stimulated gene (ISG) expression. Challenging this dogma, we discovered that interferon-epsilon (IFNɛ), a type-I IFN first identified in female reproductive epithelia, is constitutively expressed by spermatogenic cells and macrophages in mouse and human testes. Moreover, mice lacking IFNɛ are more susceptible to viral epididymo-orchitis. The mechanisms of IFNɛ-mediated anti-viral protection in the testis were examined in this study.

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Interferon epsilon as a novel anti-viral agent in the testis [mouse]

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Interferon epsilon as a novel anti-viral agent in the testis [mouse]

Project description:Interferon epsilon as a novel anti-viral agent in the testis [mouse]

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Interferon epsilon as a novel anti-viral agent in the testis

Project description:This SuperSeries is composed of the SubSeries listed below.

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Investigation of the anti-tumour properties of interferon epsilon in high grade serous ovarian cancer in vivo.

Project description:This experiment is part of a larger study examining the anti-tumour properties of interferon epsilon in ovarian cancer. The goal of this experiment was to test the direct effects of interferon epsilon and interferon beta on human ovarian tumours in vivo, using patient derived xenografts (PDX) in immunocompromised (NSG) mice.

2023-03-28 | GSE201337 | GEO

Investigation of the direct activity of interferon epsilon on ID8 ovarian cancer cells in vitro.

Project description:This experiment is part of a larger study examining the anti-tumour properties of interferon epsilon in ovarian cancer. The objective of this experiment was to examine the direct activity of interferon epsilon on the mouse ovarian cancer cell line, ID8, and compare it to equivalent unit concentrations of interferon beta. The goal was to determine whether interferon epsilon and interferon beta induce different patterns of gene expression in ID8 cells.

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Interferon ε protects primary macrophages against HIV infection

Project description:Interferon ε (IFNε) is a unique type I IFN that is not induced by pattern-recognition response elements. IFNε is constitutively expressed in mucosal tissues including the female genital mucosa. We show here that IFNε induces an antiviral state in human macrophages that blocks HIV-1 replication. In this work, we examined effects and underlying mechanisms of IFNε in HIV infection of monocyte-derived macrophages (MDMs). We found that IFNε blocked HIV replication in macrophages. It acted on early stages of the HIV life cycle including entry and reverse transcription. It did not appear to operate through known IFN-induced HIV host restriction factors. IFNε induced immune responses in primary macrophages distinct from those induced by IFNα. Importantly, we discovered a novel protective effect of IFNε in primary macrophages against HIV by surging reactive oxygen species (ROS).

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