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Interferon epsilon as a novel anti-viral agent in the testis [human]

ABSTRACT: Interferon epsilon as a novel anti-viral agent in the testis [human]

PROVIDER: PRJNA1063600 | ENA |

REPOSITORIES: ENA

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Interferon epsilon as a novel anti-viral agent in the testis

Project description:Interferon epsilon as a novel anti-viral agent in the testis

| PRJNA1065943 | ENA

Interferon epsilon as a novel anti-viral agent in the testis [human]

Project description:The testis is susceptible to viral infections, which can impair fertility. Spermatogenic cells were thought to lack anti-viral defences, including interferon (IFN) or IFN-stimulated gene (ISG) expression. Challenging this dogma, we discovered that interferon-epsilon (IFNɛ), a type-I IFN first identified in female reproductive epithelia, is constitutively expressed by spermatogenic cells and macrophages in mouse and human testes. Moreover, mice lacking IFNɛ are more susceptible to viral epididymo-orchitis. The mechanisms of IFNɛ-mediated anti-viral protection in the testis were examined in this study.

2024-10-18 | GSE252991 | GEO

Interferon epsilon as a novel anti-viral agent in the testis [mouse]

2024-10-18 | GSE253517 | GEO

Interferon epsilon as a novel anti-viral agent in the testis [mouse]

Project description:Interferon epsilon as a novel anti-viral agent in the testis [mouse]

| PRJNA1065946 | ENA

Interferon epsilon as a novel anti-viral agent in the testis

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-18 | GSE253518 | GEO

Investigation of the anti-tumour properties of interferon epsilon in high grade serous ovarian cancer in vivo.

Project description:This experiment is part of a larger study examining the anti-tumour properties of interferon epsilon in ovarian cancer. The goal of this experiment was to test the direct effects of interferon epsilon and interferon beta on human ovarian tumours in vivo, using patient derived xenografts (PDX) in immunocompromised (NSG) mice.

2023-03-28 | GSE201337 | GEO

Investigation of the direct activity of interferon epsilon on ID8 ovarian cancer cells in vitro.

Project description:This experiment is part of a larger study examining the anti-tumour properties of interferon epsilon in ovarian cancer. The objective of this experiment was to examine the direct activity of interferon epsilon on the mouse ovarian cancer cell line, ID8, and compare it to equivalent unit concentrations of interferon beta. The goal was to determine whether interferon epsilon and interferon beta induce different patterns of gene expression in ID8 cells.

2023-03-28 | GSE201345 | GEO

Interferon ε protects primary macrophages against HIV infection

Project description:Interferon ε (IFNε) is a unique type I IFN that is not induced by pattern-recognition response elements. IFNε is constitutively expressed in mucosal tissues including the female genital mucosa. We show here that IFNε induces an antiviral state in human macrophages that blocks HIV-1 replication. In this work, we examined effects and underlying mechanisms of IFNε in HIV infection of monocyte-derived macrophages (MDMs). We found that IFNε blocked HIV replication in macrophages. It acted on early stages of the HIV life cycle including entry and reverse transcription. It did not appear to operate through known IFN-induced HIV host restriction factors. IFNε induced immune responses in primary macrophages distinct from those induced by IFNα. Importantly, we discovered a novel protective effect of IFNε in primary macrophages against HIV by surging reactive oxygen species (ROS).

2016-10-03 | GSE83716 | GEO

IKK-epsilon regulates the balance between the type I and type II interferon responses

Project description:Virus infection induces the production of type I and type II interferons (IFN-I and IFN-II), cytokines that mediate the antiviral response. IFN-I (IFN-a and -b) induces the assembly of ISGF3 (interferon-stimulated gene factor 3), a multimeric transcriptional activation complex comprised of STAT1, STAT2 and IRF9. IFN-II (IFN-g) induces the homodimerization of STAT1 to form the GAF (gamma-activated factor) complex. ISGF3 and GAF bind specifically to distinct regulatory DNA sequences located upstream of IFN-I and II inducible genes, respectively, and activate the expression of distinct set of antiviral genes. The balance between the type I and type II IFN pathways plays a critical role in orchestrating the innate and adaptive immune systems. Here, we show that the phosphorylation of STAT1 by IKKε (IkB-related kinase epsilon) inhibits STAT1 homodimerization, and thus GAF formation, but does not disrupt ISGF3 formation. Therefore, virus and/or IFN-I activation of IKKε suppresses GAF-dependent transcription and promotes ISGF3-dependent transcription. In the absence of IKKε, GAF-dependent transcription is enhanced at the expense of ISGF3-mediated transcription, rendering cells less resistant to infection. We conclude that IKKε plays a critical role in regulating the balance between the IFN-I and IFN-II signaling pathways. ChIP-seq libraries were constructed with an antibody targeting STAT1 from bone marrow macrophages treated with interferon

2011-12-01 | E-GEOD-33913 | biostudies-arrayexpress

Investigation of the anti-tumour properties of interferon epsilon in high grade serous ovarian cancer

Project description:Investigation of the anti-tumour properties of interferon epsilon in high grade serous ovarian cancer

| PRJNA832125 | ENA