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The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila.

ABSTRACT: The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila.

PROVIDER: PRJNA1063668 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27503835.fastq.gz	Fastqsanger.gz
	SRR27503836.fastq.gz	Fastqsanger.gz
	SRR27503837.fastq.gz	Fastqsanger.gz
	SRR27503838.fastq.gz	Fastqsanger.gz
	SRR27503839.fastq.gz	Fastqsanger.gz

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The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [ChIP-seq]

Project description:Evolutionary analyses have estimated that ~60% of nucleotides in intergenic regions of the Drosophila melanogaster genome are functionally relevant, suggesting that regulatory information may be encoded more densely in intergenic regions than has been revealed by most functional dissections of regulatory DNA. Here, we approached this issue through a functional dissection of the regulatory region of the gene shavenbaby (svb). Most of the ~90 kilobases of this large regulatory region is highly conserved in the genus Drosophila, though characterized enhancers occupy a small fraction of this region. By analyzing the regulation of svb in different contexts of Drosophila development, we found that the regulatory information that drives svb expression in the abdominal pupal epidermis is organized in a different way than the elements that drive svb expression in the embryonic epidermis. While in the embryonic epidermis svb is activated by compact enhancers separated by large inactive DNA regions, svb expression in the pupal epidermis is driven by regulatory information distributed over broader regions of svb cis-regulatory DNA. In the same vein, we observed that other developmental genes also display a dense distribution of putative regulatory elements in their regulatory regions. Furthermore, we found that a large percentage of conserved non-coding DNA of the Drosophila genome is contained within regions of open chromatin. These results suggest that part of the evolutionary constraint on non-coding DNA of Drosophila is explained by the density of regulatory information, which may be greater than previously appreciated.

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The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [ATAC-seq]

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The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [CUT&RUN]

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The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [ChIP-seq]

Project description:The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [ChIP-seq]

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The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [CUT&RUN]

Project description:The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [CUT&RUN]

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The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila [ATAC-seq]

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The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila.

Project description:This SuperSeries is composed of the SubSeries listed below.

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