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ABSTRACT: Columba livia (rock pigeon) genome, bColLiv1

PROVIDER: PRJNA1063711 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
		Other
	SRR30144400.fastq.gz	Fastqsanger.gz
	SRR30172931_1.fastq.gz	Fastqsanger.gz
	SRR30172931_2.fastq.gz	Fastqsanger.gz

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Project description:Columba livia (rock pigeon) genome, bColLiv1, sequence data

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Investigating genome occupancy of SOX10 in avian melanocytes

Project description:Domestic rock pigeons (Columba livia) homozygous for either of two “recessive red” mutations, which are partially-overlapping deletions causing downregulation of Sox10, display brilliant red colors instead of blue/black feathers. Sox10 encodes a transcription factor important for melanocyte differentiation and function, but the precise role that it plays in promoting eumelanin over pheomelanin pigment production in pigeons are unknown. In this study, we perform ChIPseq for SOX10, H3K27ac, and H3K27me3 to better understand the genome occupancy of SOX10 in avian melanocytes.

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SOX10 regulates multiple genes to direct eumelanin vs. pheomelanin production in domestic rock pigeon

Project description:The domesticated rock pigeon (Columba livia) has been bred for hundreds of years to display an immense variety of ornamental attributes such as feather color and color patterns. Color is influenced by multiple loci that impact the type and amount of melanin deposited on the feathers. Pigeons homozygous for the “recessive red” mutation, which causes downregulation of Sox10, display brilliant red feathers instead of blue/black feathers. Sox10 encodes a transcription factor important for melanocyte differentiation and function, but the genes that mediate its promotion of black vs. red pigment are unknown. Here, we present a transcriptomic comparison of regenerating feathers from wild-type and recessive red pigeons to identify candidate SOX10 targets. Our results identify both known and novel targets, including many genes not previously implicated in pigmentation. These data highlight the value of using novel, emerging model organisms to gain insight into the genetic basis of pigment variation.

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Columba livia breed:White King Pigeon

Project description:Columba livia breed:White King Pigeon Genome sequencing

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