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Navel Orange Peel Essential Oil Inhibits the Growth and Progression of Triple Negative Breast Cancer

ABSTRACT: Navel Orange Peel Essential Oil Inhibits the Growth and Progression of Triple Negative Breast Cancer

PROVIDER: PRJNA1063786 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27497248_1.fastq.gz	Fastqsanger.gz
	SRR27497248_2.fastq.gz	Fastqsanger.gz
	SRR27497249_1.fastq.gz	Fastqsanger.gz
	SRR27497249_2.fastq.gz	Fastqsanger.gz
	SRR27497250_1.fastq.gz	Fastqsanger.gz

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Navel Orange Peel Essential Oil Inhibits the Growth and Progression of Triple Negative Breast Cancer

Project description:Triple Negative Breast Cancer (TNBC) is a particular type of breast cancer with the highest mortality rate and there has been growing concern about the development of essential oils as potential anti-cancer drugs.This investigation explored the bioactivity and molecular mechanisms of navel orange peel oil (NOPEO) against TNBC cells. By initiating cell cycle block and apoptosis, NOPEO demonstrated potent growth suppressive properties on the TNBC cell lines MDA-MB-231 and MDA-MB-453. NOPEO was also effective in inhibiting the motility of MDA-MB-231 cells and in down-regulating the levels of MMP-9 and MMP-2 proteins. Additionally, NOPEO's inhibitory effects on MDA-MB-231 gene expression were analysed by RNA sequencing. In total, 1376 genes were found to be upregulated and 1335 genes were downregulated after NOPEO treatment. According to KEGG and GO pathways, the differentially expressed genes were related to MAPK, Jak/stat and FoxQ signalling pathways.

2024-06-20 | GSE253079 | GEO

Microarray Based Analysis of the Developing Sweet Orange Transcriptome

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Comparison of transcriptomes in five varieties of citrus fruit

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Microarray Based Analysis of the Developing Sweet Orange Transcriptome

Project description:Using a custom microarray platform, we examined expression of 366 genes in leaf, two peel tissues, juice sac, and whole fruit during various developmental stages of Washington Navel orange fruit (Citrus sinensis L. Osbeck). 366 genes were chosen from Citrus EST libraries by in-silico analysis method. Keywords: time course and tissue comparison Study to compare gene expression between peel layers and over time as fruit matured. Samples taken from leaf tissue, whole fruit at 24 and 38 days after full bloom (DAFB), and from albedo and flavedo layers of the peel at 80 and 165 DAFB, and flavedo from mature fruit at 220 DAFB. In all cases except one, there were three technical replicates hybridized for each Sample simultaneously.

2010-05-26 | E-GEOD-10731 | biostudies-arrayexpress

Citrus sinensis cultivar:Parent Washington navel orange

Project description:Citrus sinensis cultivar:Parent Washington navel orange Assembly

| PRJNA944215 | ENA

Transcriptome analysis to elucidate puffing disorder in Citrus

Project description:To identify genes associated with citrus peel development and manifestation of peel disorders, we analyzed flavedo, albedo and juice sac tissues from navel orange displaying, and not displaying, the puff disorder. Symptomatic and healthy M-bM-^@M-^\NavelM-bM-^@M-^] orange fruits were harvested from an orchard located in in Pauma Valley, San Diego County, California, USA. Sampling for all analysis (healthy or disordered Navel orange) was performed at the same time, from trees grown under the same agronomic, soil, and environmental conditions. Healthy and disordered fruits were analyzed at the mature stage. All transcriptome analysis was performed on mature fruit. For each type of fruit, three tissues (flavedo, albedo, and juice sacs) from three different trees (biological replicates) were separately analyzed. Four symptomatic fruits comprised one biological replicate each. Two healthy fruits comprised two biological replicates of control samples. A 1 cm-thick equatorial disc and four sections (N, S, E, and W) were cut per fruit. Each section of flavedo, albedo, and juice sac tissue was dissected. gene expression variation underlying quality trait, different genotypes

2014-01-01 | E-GEOD-49957 | biostudies-arrayexpress

Citrus sinensis cultivar:Parent Washington Navel orange

Project description:Citrus sinensis cultivar:Parent Washington Navel orange Genome sequencing and assembly

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Citrus sinensis cultivar:Parent Washington Navel orange

Project description:Citrus sinensis cultivar:Parent Washington Navel orange Genome sequencing and assembly

| PRJNA970399 | ENA

Citrus sinensis cultivar:Parent Washington Navel orange

Project description:Citrus sinensis cultivar:Parent Washington Navel orange Genome sequencing and assembly

| PRJNA970396 | ENA