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ScRNA-seq for stromal Lkb1 deficiency-induced gastrointestinal polyps

ABSTRACT: scRNA-seq for stromal Lkb1 deficiency-induced gastrointestinal polyps

PROVIDER: PRJNA1064124 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27532402_1.fastq.gz	Fastqsanger.gz
	SRR27532402_2.fastq.gz	Fastqsanger.gz
	SRR27532403_1.fastq.gz	Fastqsanger.gz
	SRR27532403_2.fastq.gz	Fastqsanger.gz
	SRR27532404_1.fastq.gz	Fastqsanger.gz

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scRNA-seq for stromal Lkb1 deficiency-induced gastrointestinal polyps

Project description:Numerous studies have showed that mesenchymal-specific Lkb1 is sufficient for the development of PJS-like polyps in mice. However, the cellular origin and component of these Lkb1-associated polyps and underlying mechanisms remain elusive. In this present study, we generated tamoxifen-inducible Lkb1flox/flox;Myh11-Cre/ERT2 mice and performed scRNA-seq to investigate the cellular complexity of gastrointestinal polyps associated with PJS.

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