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Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis [snRNA-seq]

ABSTRACT: Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis [snRNA-seq]

PROVIDER: PRJNA1064411 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27536901_1.fastq.gz	Fastqsanger.gz
	SRR27536901_2.fastq.gz	Fastqsanger.gz
	SRR27536902_1.fastq.gz	Fastqsanger.gz
	SRR27536902_2.fastq.gz	Fastqsanger.gz
	SRR27536903_1.fastq.gz	Fastqsanger.gz

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Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis [snRNA-seq]

Project description:Objective: To identify and characterize celltypes and distinct transcriptomic signatures present in the infrapatellar fat pad (IFP) of knee OA patients using single-nucleus RNA sequencing.

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Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis [Spatial Transcriptomics]

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Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis

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Project description:The infrapatellar fat pad (IFP) is involved in the occurrence and progression of osteoarthritis (OA), yet the proteomic changes in the IFP during OA are not well understood. In this study, we selected the IFP from patients undergoing late-stage total knee arthroplasty as the experimental group, while the IFP from patients undergoing repair surgery for acute anterior cruciate ligament rupture served as the control group. Using label-free protein quantification technology, we analyzed the protein expression levels in the experimental and control groups. We identified 315 differentially expressed proteins that are primarily associated with functions such as coagulation, complement, fatty acid metabolism, and adipogenesis. These findings shed light on the potential molecular mechanisms underlying the involvement of the IFP in OA pathogenesis.

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Synovium and Infrapatellar fat pad are one functional tissue unit sharing common mesenchymal progenitors and undergoing coordinated changes in osteoarthritis

Project description:The Infrapatellar fat pads (IFP) are two wedge shaped fatty structures situated below the kneecap (patella), lying either side of the patellar tendon, first described by Hoffa in 1904. Recent studies reveal that knee OA causes pathological fibrosis, stiffening, and inflammation of the synovium and IFP (4, 5) (6). Multiple groups, including our co-investigator Dr. Changhai Ding, reported that MRI signal intensity alteration in IFP is strongly associated with OA knee structural abnormalities and may serve as an imaging biomarker to predict OA progression in patients (7-10). However, we have limited knowledge regarding the regulation of synovium and IFP functions for joint homeostasis and OA development.

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