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Lifestyle-induced changes in alternative splicing patterns in mice

ABSTRACT: Lifestyle-induced changes in alternative splicing patterns in mice

PROVIDER: PRJNA1064581 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR27544258_1.fastq.gz	Fastqsanger.gz
	SRR27544258_2.fastq.gz	Fastqsanger.gz
	SRR27544259_1.fastq.gz	Fastqsanger.gz
	SRR27544259_2.fastq.gz	Fastqsanger.gz

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Lifestyle-induced changes in alternative splicing patterns in mice [adipose]

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Lifestyle-induced changes in alternative splicing patterns in mice [adipose]

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p38 SAPK and SKIIP induced changes in alternative splicing patterns upon osmostress

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p38 SAPK and SKIIP induced changes in alternative splicing patterns upon osmostress

Project description:Alternative splicing is a crucial mechanism for gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps of mRNA biogenesis. Here, we show that osmostress has a major impact on the regulation of alternative splicing (AS), which is partly mediated through the action of the p38 SAPK. Remarkably, a splicing network analysis revealed a functional connection between p38 and the spliceosome component SKIIP. Depletion of SKIIP abolished a significant part of the p38-mediated alternative splicing.

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Lifestyle-induced changes in alternative splicing patterns in mice

Project description:This SuperSeries is composed of the SubSeries listed below.

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Heat stress induced alternative splicing in a species-dependent manner

Project description:Patterns of alternative splicing during heat stress in Arabidopsis thaliana and Boechera depauperata indicate complex and species-specific interactions between differential expression and alternative splicing.

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Genomewide analysis of EGF-induced alternative splicing

Project description:We performed EGF treatment and hnRNP A1 knockdown in HeLa cells and analyzed alternative splicing patterns by high-throughput RNA sequencing.

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Alternative splicing changes in A. fumigatus sensitized mice

Project description:Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Aspergillus fumigatus (A. fumigatus)-sensitized mice and an exon junction microarray to detect potential changes in alternative splicing. One of the sensitization-associated changes identified in the search was a shift in alternative splicing of the mRNA encoding cFLIP, a modulator of the caspase- mediated extrinsic apoptosis pathway. Expanding these studies to human asthma patients, we discovered a significant decrease in the expression of both cFLIP isoforms in severe corticosteroid- resistant asthmatics. Although it is unclear whether these changes were due solely to differences in alternative splicing, these findings provide evidence that dysregulation of the extrinsic apoptosis pathway is part of the underlying immunopathogenesis of severe refractory asthma. The technical side of the microarray experiment was essentially the Illumina protocol.

2014-01-14 | E-GEOD-28258 | biostudies-arrayexpress

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