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Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis [Bulk RNA-seq]

ABSTRACT: Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis [Bulk RNA-seq]

PROVIDER: PRJNA1064989 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27554450.fastq.gz	Fastqsanger.gz
	SRR27554451.fastq.gz	Fastqsanger.gz
	SRR27554452.fastq.gz	Fastqsanger.gz
	SRR27554453.fastq.gz	Fastqsanger.gz
	SRR27554454.fastq.gz	Fastqsanger.gz

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Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis [scRNA-seq]

Project description:Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncover a dominant role for type 2 innate lymphoid cells (ILC2) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2 by androgens leads to a reduction in dendritic cell (DC) accumulation and activation in males, and reduced tissue immunity. Collectively, this work uncovers an androgen-ILC2-DC axis in controlling sexual immune dimorphism. Moreover, this work proposes that tissue immune set-points are defined by the dual action of sex hormones and the microbiota, with sex hormones controlling the strength of local immunity and microbiota calibrating its tone.

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Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis [Bulk RNA-seq]

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Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis

Project description:Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis

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Project description:Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis [scRNA-seq]

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Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis

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