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Expression microarray comparison of medulloblastoma in Math1-Cre/SmoM2 mice with and without Cre-conditional Bcl2l1 deletion

ABSTRACT: Expression microarray comparison of medulloblastoma in Math1-Cre/SmoM2 mice with and without Cre-conditional Bcl2l1 deletion

PROVIDER: PRJNA1065474 | ENA |

REPOSITORIES: ENA

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Expression microarray comparison of medulloblastoma in Math1-Cre/SmoM2 mice with and without Cre-conditional Bcl2l1 deletion

Project description:We compared gene expression in medulloblastomas in mice with conditional Bcl2l1 deletion versus medulloblastomas in mice with WT Bcl2l1. We generated mice with medulloblastomas by crossing Math1-Cre and SmoM2 mouse lines. We generated mice with medulloblastomaswith Cre-conditional Bcl2l1 deletion by breeding Bcl2l1 f/f mice into both Math1-Cre and SmoM2 mouse lines. We harvested tumors at P15 and then isolated RNA for expression array analysis.

2025-01-13 | GSE253408 | GEO

RNA-sequencing of the Math1-Cre SmoM2 mouse genetic model of medulloblastoma

Project description:RNA-sequencing of the Math1-Cre SmoM2 mouse genetic model of medulloblastoma

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scRNA-seq analysis of SHH medulloblastomas in Math1-Cre/SmoM2 mice with homozygous or heterozygous co-deletion of Bcl2l1 (aka Bcl-xL)

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scRNA-seq analysis of SHH medulloblastomas in Math1-Cre/SmoM2 mice with homozygous or heterozygous co-deletion of Bcl2l1 (aka Bcl-xL)

Project description:We found that medulloblastomas that form in Smo mutant mice grow more slowly when the animals are genetically engineered so that the gene Bcl2l1 is conditionally deleted in the tumor cells. We undertook this study to define changes in cellular heterogeneity and gene expression patterns in the Bcl2l1-deleted medulloblastomas, compared to medulloblastomas with an intact Bcl2l1 allele.

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Project description:This dataset includes the raw single-cell RNAseq data from Math1-Cre;SmoM2 mouse medulloblastoma model at P7.

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RNA Sequencing of postnatal mouse Math1-Cre; Sufu flox/- cerebellum

Project description:Transcriptional profiling to identify genes differentially regulated by Sufu during cerebellum development. Sufu was specifically deleted from the granule neuron compartment using Math1-driven Cre recombinase.

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Mechanosensing brain tumor cells construct blood-tumor barrier to mask chemosensitivity

Project description:This dataset includes the raw single-cell RNAseq data from Math1-Cre;SmoM2 and Math1-Cre;SmoM2;Piezo2 fl/fl mouse medulloblastoma model. In this project, we focused on transcriptomic alteration caused by Piezo2 knockout in Sox2 positive MB initiation cells.

2022-09-22 | GSE197402 | GEO

RNA-sequencing of the Math1-Cre SmoM2 mouse genetic model of medulloblastoma

Project description:We investigated how misactivation of the Hedgehog (Hh) pathway causes medulloblastoma, and found that Hh signaling induces its transcriptional effector GLI2 to bind the Cdk6 promoter, activate gene expression, and drive uncontrolled cell proliferation. Genetic or pharmacological inhibition of CDK6 repressed the growth of Hh-associated medulloblastoma and prolonged survival in vivo through inhibition of cell proliferation. These findings suggest that CDK6 antagonists may be effective therapies for Hh-associated cancers in humans.

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RNA Sequencing of postnatal mouse Math1-Cre Sufu flox/- cerebellum

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Gene expression in mice with conditional over-activation of hedgehog signaling in the ovary

Project description:The objective of the study was to determine the cause of anovulation in transgenic mice with conditional over-activation of the hedgehog signaling pathway in the ovary. In Amhr2(cre/+)-SmoM2 transgenic mice, a constitutively active version of the hedgehog signal transducer, smoothened (SMO), known as SMOM2, is expressed in the ovary following cre-mediated recombination. The hypothesis tested is that changes in the neonatal ovary caused by over-activation of hedgehog signaling leads to the life-long anovulation phenotype in transgenic mice. Microarrays were used to examine differences in gene expression in ovaries of two day old wild-type mice (Amhr2(+/+)-SmoM2) and transgenic mice (Amhr2(cre/+)-SmoM2) in which the hedgehog signaling pathway was conditionally over-activated in the ovary. Two microarrays were performed. RNA samples were prepared from ovaries of 8 Amhr2(+/+)-SmoM2 control mice and 8 Amhr2(cre/+)-SmoM2 mutant mice on day two of age. RNA quality was assessed by measurement of ribosomal RNA on an Agilent 2100 Bioanalyzer.

2012-03-14 | E-GEOD-35123 | biostudies-arrayexpress

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