ABSTRACT: Application of metagenomic Next Generation Sequencing in clinically suspected central nervous system infection after neurological surgeries-a prospective study
Project description:Identification of fungal species present in the central nervous system tissue from Alzheimer's disease patients by next-generation sequencing.
Project description:MS is a primary demyelinating disease of the central nervous system. The cause is unknown and pathological hallmarks include plaque formation with immune cell infiltration. A microarray analysis of characterized brain tissue samples from three MS cases and a non-neurological control sample was performed containing over 22,000 genes. Real-time PCR analyses of 7 MS samples and 3 non-neurological control brain samples confirmed changes in expression in the chosen genes of interest. Experiment Overall Design: Three MS cases and a non-neurological control sample were used.
