Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Phylogenomics identifies parents of naturally occurring tetraploid bananas

PROVIDER: PRJNA1066417 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27665500_1.fastq.gz	Fastqsanger.gz
	SRR27665500_2.fastq.gz	Fastqsanger.gz
	SRR27665501_1.fastq.gz	Fastqsanger.gz
	SRR27665501_2.fastq.gz	Fastqsanger.gz
	SRR27665502_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 26

Similar Datasets

Gene expression profile of diploid and tetraploid mouse primary hepatocyte

Project description:Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest that ~37% of human tumors have undergone a genome-doubling event during their development. This potentially oncogenic effect of tetraploidy is countered by a p53-dependent barrier to proliferation. However, the cellular defects and corresponding signaling pathways that trigger growth suppression in tetraploid cells are not known. Here we combine genome-scale RNAi screening and in vitro evolution approaches to demonstrate that cytokinesis failure activates the Hippo tumor suppressor pathway in cultured cells as well as in naturally occurring tetraploid cells in vivo. Induction of the Hippo pathway is triggered in part by extra centrosomes, which alter small G-protein signaling and activate LATS2 kinase; LATS2 in turn stabilizes p53 and inhibits the transcriptional regulators YAP and TAZ. These findings define an important tumor suppression mechanism. Furthermore, our experiments uncover adaptations that allow nascent tumor cells to bypass this inhibitory regulation. Hepatocytes of newborn mice are initially diploid, but become progressively tetraploid with age. To study the mechanism of cell cycle arrest in naturally occurred tetraploidy, we used microarrays to detail the overall gene expression profile of diploid and tetraploid primary hepatocytes and identified YAP target genes up-regulated in diploid cells.

2017-02-10 | GSE57769 | GEO

Project description:Naturally Occurring Dog Model for Juvenile Dermatomyositis

| PRJNA338147 | ENA

uncultured virus

Project description:Sequences from naturally occurring surface water viruses

| PRJNA46235 | ENA

Project description:Naturally Occurring Alleles Diversity of StNADC Promote Foliage Senescence and Tuberization in the Tetraploid Potato (Solanum tuberosum L.)

| PRJNA917150 | ENA

RNA-seq of a P. infestans resistance segregating population with parents Desiree (cv) and breeding line SW93-1015

Project description:A segregating population was produced by crossing the tetraploid parents, the cultivar Desire and the breeding line SW93-1015. In all, 34 progeny lines were further characterized by phenotyping for multiple traits both in the field and controlled climate settings. For example the late blight resistance screening was done for the lines. Leaf transcriptomes of each line and the two parents were sequenced by Illumina HiSeq 2000 to produce RNA-seq data.

2019-04-02 | E-MTAB-5996 | biostudies-arrayexpress

Patterns of Population Epigenomic Diversity in Arabidopsis thaliana (Methyl-Seq)

Project description:Natural epigenetic variation provides a source for the generation of phenotypic diversity, but to understand its contribution to phenotypic diversity, its interaction with genetic variation requires further investigation. MethylC-seq from naturally-occurring Arabidopsis accessions

2013-03-05 | E-GEOD-43857 | biostudies-arrayexpress

Environmental effects on immunity in naturally-occurring vertebrates

Project description:Environmental effects on immunity in naturally-occurring vertebrates

| PRJEB13319 | ENA

Drosophila melanogaster

Project description:Naturally occurring copy-number polymorphism in Drosophila melanogaster

| PRJNA103499 | ENA

Project description:Fitness costs of naturally occurring viruses of Drosophila

| PRJNA1010185 | ENA

Bacteria

Project description:Naturally occurring cefotaxime resistance microbes in beef cattle

| PRJNA319130 | ENA