Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Ultraconserved element data for phylogenomic analysis of Ghatippus paschima jumping spider (Salticidae, Plexippini, Plexippina)

PROVIDER: PRJNA1067139 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27728353_1.fastq.gz	Fastqsanger.gz
	SRR27728353_2.fastq.gz	Fastqsanger.gz
	SRR27728354_1.fastq.gz	Fastqsanger.gz
	SRR27728354_2.fastq.gz	Fastqsanger.gz
	SRR27728355_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Project description:Ultraconserved element data for phylogenomic analysis of Iranattus jumping spiders (Salticidae, Plexippini, Plexippina)

| PRJNA1101580 | ENA

Project description:Cryptophyte Ultraconserved Element Phylogenomic Study

| PRJNA984198 | ENA

Project description:Revalidation of the jumping spider genus Cheliceroides based on molecular and morphological data (Araneae, Salticidae)

| PRJNA1059158 | ENA

qqSalScen

Project description:Salticus scenicus (jumping spider)

| PRJEB65213 | ENA

Project description:Promyrmekiaphila and outgroup Ultraconserved element data

| PRJNA1019074 | ENA

qqSalScen

Project description:Salticus scenicus (jumping spider), genomic and transcriptomic data

| PRJEB65212 | ENA

Habronattus

Project description:Phylogeny with introgression in Habronattus jumping spiders (Araneae: Salticidae)

| PRJNA421554 | ENA

Project description:UCE capture of Baviini and other jumping spiders (Salticidae)

| PRJNA667925 | ENA

Project description:Hirundinidae Ultraconserved Element Sequencing

| PRJNA1117501 | ENA

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies

Project description:Transposable elements, known colloquially as “jumping genes,” constitute approximately 45% of the human genome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencing heterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearance of transposable element transcripts. Here we identify transposable element activation as a key mediator of neuronal death in tauopathies, a group of neurodegenerative disorders, including Alzheimer’s disease, that are pathologically characterized by deposits of tau protein in the brain. Mechanistically, we find that heterochromatin decondensation and reduction of piwi/piRNAs drive transposable element activation in tauopathy. Using genetic and pharmacological approaches in a Drosophila melanogaster model of tauopathy, we provide evidence for a causal relationship between pathogenic tau-induced heterochromatin decondensation, piwi/piRNA depletion, active transposable element obilization, and neurodegeneration. We further report a significant increase in transcripts of the endogenous retrovirus class of transposable elements in human Alzheimer’s disease and progressive supranuclear palsy, suggesting that transposable element dysregulation is conserved in human tauopathy. Taken together, our data identify heterochromatin decondensation, piwi/piRNA depletion and consequent transposable element activation as a novel, pharmacologically targetable, mechanistic driver of neurodegeneration in tauopathy.

2018-07-04 | GSE115606 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data