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Feline leukemia virus (TaxID #11768), Minute virus of mice (TaxID # 10794 ), and Porcine circovirus 1(TaxID # 133704)

ABSTRACT: Method development for rapid adventitious virus detection during cell biomanufacturing

PROVIDER: PRJNA1067635 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27788412_1.fastq.gz	Fastqsanger.gz
	SRR27788413_1.fastq.gz	Fastqsanger.gz
	SRR27788414_1.fastq.gz	Fastqsanger.gz
	SRR27788415_1.fastq.gz	Fastqsanger.gz
	SRR27788416_1.fastq.gz	Fastqsanger.gz

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Matrine displayed antiviral activity in porcine alveolar macrophages co-infected by porcine reproductive and respiratory syndrome virus and porcine circovirus type 2.

Project description:The co-infection of porcine reproductive respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) is quite common in clinical settings and no effective treatment to the co-infection is available. In this study, we established the porcine alveolar macrophages (PAM) cells model co-infected with PRRSV/PCV2 with modification in vitro, and investigated the antiviral activity of Matrine on this cell model and further evaluated the effect of Matrine on virus-induced TLR3,4/NF-κB/TNF-α pathway. The results demonstrated PAM cells inoculated with PRRSV followed by PCV2 2 h later enhanced PRRSV and PCV2 replications. Matrine treatment suppressed both PRRSV and PCV2 infection at 12 h post infection. Furthermore, PRRSV/PCV2 co- infection induced IκBα degradation and phosphorylation as well as the translocation of NF-κB from the cytoplasm to the nucleus indicating that PRRSV/PCV2 co-infection induced NF-κB activation. Matrine treatment significantly down-regulated the expression of TLR3, TLR4 and TNF-α although it, to some extent, suppressed p-IκBα expression, suggesting that TLR3,4/NF-κB/TNF-α pathway play an important role of Matrine in combating PRRSV/PCV2 co-infection. It is concluded that Matrine possesses activity against PRRSV/PCV2 co-infection in vitro and suppression of the TLR3,4/NF-κB/TNF-α pathway as an important underlying molecular mechanism. These findings warrant Matrine to be further explored for its antiviral activity in clinical settings.

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