Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cyclosporin ameliorates right ventricular remodeling of postnatal mice with volume overload.

ABSTRACT: Cyclosporin ameliorates right ventricular remodeling of postnatal mice with volume overload.

PROVIDER: PRJNA1069016 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27725846_1.fastq.gz	Fastqsanger.gz
	SRR27725846_2.fastq.gz	Fastqsanger.gz
	SRR27725847_1.fastq.gz	Fastqsanger.gz
	SRR27725847_2.fastq.gz	Fastqsanger.gz
	SRR27725848_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Cyclosporin ameliorates right ventricular remodeling of postnatal mice with volume overload.

Project description:We reported the RNAseq analyses of right ventricular free wall of myocardium in three groups of mice（3 in each group）at postnatal day 14 (P14). The mice in volume overload (VO) group underwent an abdominal surgery by puncture from aorta to inferior vena cava at P7, mice in Sham group underwent the same surgery except for the puncture. The mice in CsA group were VO mice who were also injected with cyclosporin A(CsA) for seven days. The results revealed that there were differentially expressed genes between VO and sham group at P14, Inhibiting the immune response with CsA caused the gene expression profile of VO mice to shift towards that of sham mice.

2024-02-01 | GSE254207 | GEO

Time dependence of volume overload on right ventricular remodeling during preadolescence

Project description:Time dependence of volume overload on right ventricular remodeling during preadolescence

| PRJNA661200 | ENA

Effect of volume overload on right ventricular remodeling in neonatal SD rats

Project description:We reported the RNAseq analyses of right ventricualr free wall myocardium in neonatal volume overload (VO) SD rat. VO was induced by the fistula between abdominal aorta and inferior vena cava (AVF) within 24 hours postnatally (P1). RNAseq analyses of RV free wall at P7 from VO and sham-operated rat revealed that there were 454 differentially expressed genes between VO and sham group at P7. GO analysis showed that in the VO and sham comparison, the upregulated genes mainly mediated immune system response and the downregulated genes mainly mediated apoptotic process at P7. VO has no effect to neonatal right ventricular cardiomyocyte proliferation.

2021-12-08 | GSE180643 | GEO

Effect of volume overload on right ventricular remodeling in neonatal SD rats

Project description:Effect of volume overload on right ventricular remodeling in neonatal SD rats

| PRJNA749019 | ENA

The difference of right and left ventricular remodeling caused by volume overload in neonatal SD rats

Project description:The difference of right and left ventricular remodeling caused by volume overload in neonatal SD rats

| PRJNA773071 | ENA

Single-cell RNA-sequencing reveals the effects of right ventricular volume overload on cardiomyocyte proliferation via immune responses

Project description:Background: Right ventricular volume overload (RVVO) is one of the most important hemodynamic characteristics in children with congenital heart diseases (CHDs) and heart failure, and cardiomyocyte (CM) proliferation is a vital factor for improving cardiac performance. However, whether and how RVVO reboots CM proliferation remains elusive. Methods and Results: We first created a prepubertal RVVO mouse model by an abdominal- aorta- and inferior- vena- cava- fistula (ACF) surgery on postnatal day 7(P7). Then we performed bulk RNA-seq on RVs of RVVO mice on P14, which showed that the top 30 enriched gene ontology(GO) terms of upregulated genes were associated with cell proliferation and that cell cycle was the fourth top enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway terms. Immunofluorescence staining confirmed the results, showing significantly increased numbers of phosphorylated histone 3/Aurora B-positive CMs in RVs with RVVO when compared to those in control RVs. Single RNA-seq performed on P21 further confirmed the results, showing increased percentage of CMs, with five sub-functional CMs, in which immature CMs increased while mature CMs decreased. In addition, RNA-seq/flow cytometry demonstrated that RVVO induced an immune response. Inhibiting the immune response with cyclosporin A(CsA) caused the gene expression profile of RVVO mice to shift towards that of sham mice, with a significant decrease in cell cycle associated genes’ enrichment. Conclusions: RVVO temporarily reboots prepubertal CM proliferation via immune responses. This study may provide an opportunity to create a novel paradigm to treat pediatric CHDs or heart failure in considering the importance of RVVO and CM proliferation in CHDs or heart failure.

2024-12-06 | GSE255054 | GEO

The difference of right and left ventricular remodeling caused by volume overload in neonatal SD rats

Project description:We reported the RNAseq analyses of right ventricle (RV) and left ventricle (LV) in neonatal volume overload (VO) and sham-operated SD rat. VO was induced by the fistula between abdominal aorta and inferior vena cava (AVF) within 24 hours postnatally (P1). RNAseq analyses of RV and LV free wall of P7 from VO and sham-operated rat. It demonstrated that the 1806 differentially expressed genes (DEGs) between RV and LV at the neonatal stage were primarily enriched in GTPase mediating signal transduction, insulin signaling pathway and thyroid hormone signaling pathway. VO produced 3 more times DEGs in LV than RV . GO analysis of these DEGs demonstrated that in the top 150 enriched terms, the LV comparison and RV comparison shared 34 terms (22.7%) in common. These commonly enriched terms were primarily associated with GTPase mediating signal transduction. KEGG analysis of these DEGs demonstrated that in the top 30 enriched terms, the LV comparison and RV comparison shared 14 terms (46.7%) in common. And insulin signaling pathway and thyroid hormone signaling pathway are the top two enriched terms in common. Regarding the differently enriched GO terms, they were primarily associated with lipid metabolism and ion channel in RV and primarily associated nucleic acid metabolism in LV. The top two differently enriched KEGG terms were arrhythmogenic right ventricular cardiomyopathy (ARVC) and adipocytokine signaling pathway in RV while microRNAs in cancer and longevity regulating pathway in LV. These results were further confirmed by the determination of metabolites.

2022-12-15 | GSE186247 | GEO

Single-cell RNA-sequencing reveals the effects of right ventricular volume overload on cardiomyocyte proliferation via immune responses

Project description:Single-cell RNA-sequencing reveals the effects of right ventricular volume overload on cardiomyocyte proliferation via immune responses

| PRJNA1073434 | ENA

Transcriptional characterization of cardiomyocyte nuclei from neonatal mice with volume overload

Project description:Expression analysis of cardiomyocytes from 12 day old mice with and without left ventricular volume overload

2021-05-06 | GSE165134 | GEO

Time dependence of volume overload on left ventricular remodeling during preadolescence

Project description:Time dependence of volume overload on left ventricular remodeling during preadolescence

| PRJNA777042 | ENA