Project description:Identification of key genes controlling sugar and organic acid accumulation in wampee fruit (Clausena lansium) via genome assembly and genome-wide association analysis

| PRJNA1151229 | ENA

Clausena lansium

Project description:pan-genome of orange subfamily

| PRJNA1057246 | ENA

Anti-Neuroinflammatory Components from Clausena lenis Drake.

Project description:Clausena lenis Drake (C. lenis) is a folk medicinal herb to treat influenza, colds, bronchitis, and malaria. The 95% and 50% ethanol extract of C. lenis showed significant nitric oxide (NO) inhibition activity in BV-2 microglial cells stimulated by lipopolysaccharide (LPS). Bio-guided isolation of the active extract afforded five new compounds, including a chlorine-containing furoquinoline racemate, (±)-claulenine A (1), an amide alkaloid, claulenine B (2), a prenylated coumarin, claulenin A (3), a furocoumarin glucoside, clauleside A (4), and a multi-prenylated p-hydroxybenzaldehyde, claulenin B (5), along with 33 known ones. Their structures were determined via spectroscopic methods, and the absolute configurations of new compounds were assigned via the electronic circular dichroism (ECD) calculations and single-crystal X-ray diffraction analysis. Compounds 2, 23, 27, 28, 33, and 34 showed potent anti-neuroinflammatory effects on LPS-induced NO production in BV-2 microglial cells, with IC50 values in the range of 17.6-40.9 μM. The possible mechanism was deduced to interact with iNOS through molecular docking.

| S-EPMC8951546 | biostudies-literature

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