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ABSTRACT: Hepatic Transcriptome of Poecilia vivipara Exposed to Sanitary Sewage

PROVIDER: PRJNA1070698 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27814862_1.fastq.gz	Fastqsanger.gz
	SRR27814862_2.fastq.gz	Fastqsanger.gz
	SRR27814863_1.fastq.gz	Fastqsanger.gz
	SRR27814863_2.fastq.gz	Fastqsanger.gz
	SRR27814864_1.fastq.gz	Fastqsanger.gz

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Poecilia vivipara

Project description:Poecilia vivipara exposed to sanitary sewage

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Hepatic gene expression in chinook salmon (Oncorhynchus tshawytscha) exposed to sewage

Project description:Hepatic transcriptional profiling of fish exposed to sewage to evaluate temporal and concentration trends.

2012-12-01 | GSE38925 | GEO

Hepatic gene expression in chinook salmon (Oncorhynchus tshawytscha) exposed to sewage

Project description:Hepatic transcriptional profiling of fish exposed to sewage to evaluate temporal and concentration trends. Two experiments (Year 1 and 2), each with 6 concentrations (0%, 0.05%, 0.1%, 0.7%, 2% and 5/10%) of sewage diluted in seawater at 4 timepoints (1, 4, 8 and 16 days).

2012-12-01 | E-GEOD-38925 | biostudies-arrayexpress

Global hepatic gene expression in rainbow trout exposed to sewage effluents

Project description:Effluents from sewage treatment plants contain a mixture of micropollutants with the potential of harming aquatic organisms. Thus, addition of advanced treatment techniques to complement existing conventional methods has been proposed. Some of the advanced techniques could, however, potentially produce additional compounds affecting exposed organisms by unknown modes of action. In the present study the aim was to improve our understanding of how exposure to different sewage effluents affects fish. This was achieved by explorative microarray and quantitative PCR analyses of hepatic gene expression, as well as relative organ sizes of rainbow trout exposed to different sewage effluents (conventionally treated, granular activated carbon, ozonation (5 or 15 mg/L), 5 mg/L ozone plus a moving bed biofilm reactor, or UV-light treatment in combination with hydrogen peroxide). Exposure to the conventionally treated effluent caused a significant increase in liver and heart somatic indexes, an effect removed by all other treatments. Genes connected to xenobiotic metabolism, including cytochrome p450 1A, were differentially expressed in the fish exposed to the conventionally treated effluents, though only effluent treatment with granular activated carbon or ozone at 15 mg/L completely removed this response. The mRNA expression of heat shock protein 70 kDa was induced in all three groups exposed to ozone-treated effluents, suggesting some form of added stress in these fish. The induction of estrogen-responsive genes in the fish exposed to the conventionally treated effluent was effectively reduced by all investigated advanced treatment technologies, although the moving bed biofilm reactor was least efficient. Taken together, granular activated carbon showed the highest potential of reducing responses in fish induced by exposure to sewage effluents.

2012-05-10 | GSE37574 | GEO

Oncorhynchus mykiss

Project description:Global hepatic gene expression in rainbow trout exposed to sewage effluents

| PRJNA163639 | ENA

Hepatic gene expression in chinook salmon (Oncorhynchus tshawytscha) exposed to sewage

Project description:Hepatic gene expression in chinook salmon (Oncorhynchus tshawytscha) exposed to sewage

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Project description:Effects of 4-n-nonylphenol in liver of viviparous fish (Poecilia vivipara)

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Project description:Poecilia reticulata and Poecilia wingei Transcriptome

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Eleocharis vivipara

Project description:Transcriptome sequences of Eleocharis vivipara

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Does ketoprofen or diclofenac pose the lowest risk to fish?

Project description:Ketoprofen and diclofenac are non-steroidal anti-inflammatory drugs (NSAIDs) often used for similar indications, and both are frequently found in surface waters. Diclofenac affects organ histology and gene expression in fish at around 1 µg/L. Here, we exposed rainbow trout to ketoprofen (1, 10 and 100 µg/L) to investigate if this alternative causes less risk for pharmacological responses in fish. The bioconcentration factor from water to fish blood plasma was <0.05 (4 for diclofenac based on previous studies). Ketoprofen only reached up to 0.6‰ of the human therapeutic plasma concentration, thus the probability of target-related effects was estimated to be fairly low. Accordingly, a comprehensive analysis of hepatic gene expression revealed no consistent responses. In some contrast, trout exposed to undiluted, treated sewage effluents bioconcentrated ketoprofen and other NSAIDs much more efficiently, according to a meta-analysis of recent studies. Neither of the setups is however an ideal representation of the field situation. If a controlled exposure system with a single chemical in pure water is a reasonable representation of the environment, then the use of ketoprofen is likely to pose a lower risk for wild fish than diclofenac, but if bioconcentration factors from effluent-exposed fish are applied, the risks may be more similar.

2012-06-01 | GSE37628 | GEO

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