Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [HiChIP]

ABSTRACT: Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [HiChIP]

PROVIDER: PRJNA1071597 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27819205_1.fastq.gz	Fastqsanger.gz
	SRR27819205_2.fastq.gz	Fastqsanger.gz
	SRR27819206_1.fastq.gz	Fastqsanger.gz
	SRR27819206_2.fastq.gz	Fastqsanger.gz
	SRR27819207_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [HiChIP]

Project description:Human cytomegalovirus (HCMV) infects up to 80% of the world’s population and is linked to serious morbidity in immunocompromised individuals and newborns. Here, using multiple genome-scale assays and computational approaches, we show that HCMV infection leads to widespread changes in chromatin accessibility and chromatin looping, with hundreds of thousands of human genomic regions affected 48 hours after infection. Integrative analyses reveal that HCMV infection perturbs the Hippo signaling pathway by drastically diminishing TEA domain transcription factor 1 (TEAD1) activity. Chromatin immunoprecipitation experiments confirm extensive concordant loss of TEAD1 binding and H3K27ac active histone marks upon infection. TEAD transcription factors are direct effectors of the Hippo signaling pathway, and our data support a position for TEAD1 at the top of a hierarchy involving key developmental pathways with differential expression subsequent to HMCV infection. Known gene targets of TEAD1, including Cellular Communication Network Factor 1 (CCN1) and Thrombospondin 1 (THBS1), are significantly downregulated with HCMV infection, reflecting diminished TEAD1-mediated activity. HCMV infection reduces TEAD1 binding through four distinct mechanisms: closing of TEAD1-bound chromatin, reduction of Yes1 associated transcriptional regulator (YAP1) and phosphorylated YAP (pYAP1) levels, reduction of TEAD1 transcript and protein levels, and alteration of TEAD1 exon-6 usage. Collectively, these comprehensive genome-scale analyses reveal novel mechanisms induced by HCMV infection.

2024-12-06 | GSE254737 | GEO

Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity

Project description:Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity

| PRJNA1071598 | ENA

Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [RNA-Seq]

Project description:Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [RNA-Seq]

| PRJNA1071594 | ENA

Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [ATAC-seq]

Project description:Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [ATAC-seq]

| PRJNA1071590 | ENA

Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [ChIP-seq]

Project description:Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [ChIP-seq]

| PRJNA1071593 | ENA

Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [ChIP-seq]

2024-12-06 | GSE254736 | GEO

Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [RNA-Seq]

2024-12-06 | GSE254735 | GEO

Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity [ATAC-seq]

2024-12-06 | GSE254734 | GEO

Human cytomegalovirus infection coopts chromatin organization to modulate TEAD1 transcription factor activity

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-12-06 | GSE254741 | GEO

New targets of TEAD1 revealed by ChIP-on-chip

Project description:TEAD1 acts as a key molecule of muscle development, and trans-activates multiple target genes involved in cell proliferation and differentiation pathways. However, its target genes in skeletal muscles, regulatory mechanisms and networks are unknown. Here, we use ChIP-on-chip to identify direct target genes of TEAD1. All animal procedures were performed according to protocols approved by Hubei Province, P. R. China for Biological Studies Animal Care and Use Committee. Skeletal muscle tissues were collected from three adult Kunming mice.

2011-02-01 | E-GEOD-26107 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data