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MiR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [PAR-CLIP]

ABSTRACT: miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [PAR-CLIP]

PROVIDER: PRJNA1071699 | ENA |

REPOSITORIES: ENA

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miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [PAR-CLIP]

Project description:In this study, we evaluated genetic mouse models of inducible renal epithelia-specific miR-17~92 loss-of-function and gain-of-function using unilateral ureteral obstruction. We utilized PAR-CLIP in HK2 cells to identify miR-17/-20a targets, which we subsequently validated in vitro. We examined expression of a novel miR-17/-20a target in human nephrectomy samples with varying degrees of fibrosis. We identify an activator of Hippo signaling, FERM domain-containing protein 6 (FRMD6, also known as Willin), as a novel miR-17/20a target. Frmd6 is upregulated in tubular epithelium of obstructed kidneys that lack miR-17~92, along with increased phosphorylation of Smad3 and STAT3, two known miR-17~92 profibrotic targets. Frmd6 overexpression is sufficient to result in elevated secretion of the extracellular matrix component collagen III in vitro. Finally, we demonstrate that FRMD6 expression is associated with collagen III expression in human nephrectomy samples.Our findings demonstrate that the miR-17~92 cluster in renal epithelia functions in an anti-fibrotic manner by regulating multiple pro-fibrotic pathways. We also identify Frmd6 as a novel miR-17/20a target in renal epithelia, which may drive renal fibrosis.

2025-01-30 | GSE254785 | GEO

miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [RNA-seq]

2025-01-30 | GSE254782 | GEO

miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [miRNA-seq]

2025-01-30 | GSE254784 | GEO

miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia

Project description:miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia

| PRJNA1071693 | ENA

miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [miRNA-seq]

Project description:miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [miRNA-seq]

| PRJNA1071690 | ENA

miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [RNA-seq]

Project description:miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia [RNA-seq]

| PRJNA1071691 | ENA

miR-17/20a mitigates interstitial fibrosis by repressing Frmd6 expression in renal epithelia

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-01-30 | GSE254786 | GEO

Pseudomonas parafulva strain:20a

Project description:Pseudomonas parafulva 20a genome sequencing

| PRJNA442837 | ENA

QK-knockdown U87 transduced with miR-20a or a scrambled non-targeting microRNA (miR-NT)

Project description:Identify potential miR-20a regulated mRNAs and linked pathways in the setting of QK knockdown by comparing the transcriptional profiles of shQK-transduced human U87 cells together with miR-20a or a scrambled miRNA control (miR-NT)

2009-12-30 | GSE19690 | GEO

QK-knockdown Hs683 transduced with miR-20a or a scrambled non-targeting microRNA (miR-NT)

Project description:Identify potential miR-20a regulated mRNAs and linked pathways in the setting of QK knockdown by comparing the transcriptional profiles of shQK-transduced human Hs683 cells together with miR-20a or a scrambled miRNA control (miR-NT)

2009-12-30 | GSE19688 | GEO

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