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Metabolic effects of cesarean section induced gut microbial dysbiosis in high-fat diet induced obese mice

ABSTRACT: Metabolic effects of cesarean section induced gut microbial dysbiosis in high-fat diet induced obese mice

PROVIDER: PRJNA1071717 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27822302_1.fastq.gz	Fastqsanger.gz
	SRR27822302_2.fastq.gz	Fastqsanger.gz
	SRR27822303_1.fastq.gz	Fastqsanger.gz
	SRR27822303_2.fastq.gz	Fastqsanger.gz
	SRR27822304_1.fastq.gz	Fastqsanger.gz

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Metabolic effects of cesarean section induced gut microbial dysbiosis in high-fat diet induced obese mice

Project description:The aim of this study was to investigate the causative effect of CS induced dysbiosis on obesity and insulin resistance in a high-fat diet induced obese (DIO) mouse model. Male germ-free BALB/c mice were humanized by fecal microbiota transfer using samples from children born by CS or VD and fed HFD for 16 weeks. Adipose tissue was sampled for RNAseq at study termination.

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Lactobacillus reverses cesarean section-induced colitis susceptibility in offspring: A role in maintaining ILC3 homeostasis

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Lactobacillus reverses cesarean section-induced colitis susceptibility in offspring: A role in maintaining ILC3 homeostasis

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Transcription profiling of human placentas delivered by term spontaneous labour compared to those delivered by elective term Cesarean section

Project description:Differentially expressed mRNA transcripts in the placenta delivered by term spontaneous labour compared to those delivered by elective term cesarean section. We hypothesized that the labour process involves changes in mRNA expression in the placenta. To test this hypothesis, we interrogated the mRNA levels of >50,000 genes and transcript variants using gene expression microarray (Human Genome U133 Plus 2.0 Array, Affymetrix) on 5 placentas collected from term spontaneous delivery and another 5 placentas collected from elective term cesarean delivery. To minimize the effect of gestational age on gene expression, these two groups of placentas were matched for their gestational ages at delivery. We have identified 134 and 128 genes that were up- or down-regulated, respectively, for more than 3-fold in the term (spontaneous) labour placentas compared to the term (elective) cesarean placentas (Mann-Whitney Rank Sum Test, p-value <= 0.05 after Benjamini and Hochberg adjustment for multiple testing). Experiment Overall Design: Placentas collected from (i) term spontaeous labour and (ii) elective term cesarean section were subjected to RNA extraction and hybridization on Affymetrix microarrays. To identify gene expression patterns that are commonly involved in term spontaneous labour, we analyzed 5 placentas from each of these 2 groups and tested for any differentially expressed genes by non-parametric statistical methods.

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Placentas delivered by term spontaneous labour compared to those delivered by elective term Cesarean section

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Project description:Vaginal dysbiosis in pregnancy associates with risk of emergency cesarean section

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Identification of a Myometrial Molecular Profile for Dystocic Labor

Project description:This study identifies a transciptomic myometrial profile associated with dystocia in spontanous nulliparous term labour We used microarrays to compare myometrial biopsies obtained at cesarean section from women in spontaneous term labour Women in spontaneous labour undergoing cesarean section for dystocia (slow progressing labour) compared to women who had progressed in the second stage

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