Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of STN1 knockdown on gene expression of PDAC cell lines

ABSTRACT: Effect of STN1 knockdown on gene expression of PDAC cell lines

PROVIDER: PRJNA1072721 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27848237_1.fastq.gz	Fastqsanger.gz
	SRR27848237_2.fastq.gz	Fastqsanger.gz
	SRR27848238_1.fastq.gz	Fastqsanger.gz
	SRR27848238_2.fastq.gz	Fastqsanger.gz
	SRR27848239_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Effect of STN1 knockdown on gene expression of PDAC cell lines

Project description:We aimed to elucidate the mechanistic involvement of STN1 in facilitating the metastatic processes of PDAC. Utilizing RNA-seq profiling, we observed a substantial downregulation of the EMT pathway in PANC-1 cells with stable STN1 knockdown

2024-12-31 | GSE254968 | GEO

CD73 knockdown effect in pancreatic cancer cell lines

Project description:CD73 knockdown effect in pancreatic cancer cell lines

| PRJNA480855 | ENA

Microarray analysis of Lynx1 modulation in human PDAC cell lines

Project description:A microarray was performed in order to screen the changes in gene expression following Lynx1 knockdown in 2 human PDAC cell lines Miapaca and BXPC3 and using two specific siRNA to Lynx1

2020-09-01 | GSE152505 | GEO

Effect of FOSL1 and HDAC2 knockdown on gene expression in cancer cell lines

Project description:Effect of FOSL1 and HDAC2 knockdown on gene expression in cancer cell lines

| PRJNA962475 | ENA

Effect of Aurora-A knockdown on gene expression in murine CRC cell lines.

Project description:Effect of Aurora-A knockdown on gene expression in murine CRC cell lines.

| PRJNA1036129 | ENA

Effect of TUC338 knockdown on gene expression

Project description:Effect of TUC338 knockdown on gene expression

| PRJNA433365 | ENA

RNA-seq of human PDAC cell lines PANC-1 and BxPC3 treated with Gemcitabine compared to untreated controls

Project description:Gemcitabine is commonly used for the treatment of PDAC, here we assess the effect of gene expression in human PDAC cell lines.

2023-12-05 | GSE249302 | GEO

Genome wide gene expression profile of pancreatic ductal adenocarcinoma (PDAC) cells after knock down of focal adhesion kinase (FAK).

Project description:In our experiments, we showed that FAK regulates PDAC clonogenicity and selfrenewal. In order to evaluate the impact of FAK knockdown on the transcriptomes of PDAC , we knocked down FAK in two PDAC cell lines and compared the gene expression signatures with the cancer stem cell (CSC)associated gene signatures by GSEA analysis. CCS related gene profile was inversely related with FAK-knockdown gene signature.

2017-04-20 | GSE97488 | GEO

Effect of existence or depletion of LIN28B on gene expression during tumor growth of PDAC cells

Project description:To investigate the effect of existence or depletion of LIN28B in PDAC growth , we established cell lines with or without LIN28B expression. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different cells.Additionally, we performed the whole exome sequencing of 14837T and 15376T to compare their differences

2023-09-14 | GSE217378 | GEO

Effect of TNFα and RELA inhibition on gene expression in human PDAC cells

Project description:The canonical NF-κB transcription factor RELA is a master regulator of immune and stress responses and is upregulated in PDAC tumours. Here, we characterised previously unknown endogenous RELA-GFP dynamics in PDAC cell lines by live single cell imaging, which revealed rapid, sustained and non-oscillatory nuclear RELA following TNFα stimulation. Using Bayesian analysis of single cell datasets with variation in nuclear RELA, we predicted that RELA heterogeneity in PDAC cell lines is dependent on F-actin dynamics. Using RNA-seq, we identified the actin regulators NUAK2 and ARHGAP31 as transcriptionally regulated by RELA. In turn, NUAK2 or ARHGAP31 siRNA depletion downregulates TNFα-stimulated RELA nuclear localisation in PDAC cells, establishing a novel negative feedback loop regulating RELA activation by TNFα. We identify an additional actin-independent feedback loop involving RELB, which suppresses TNFα-mediated RELA nuclear localisation following RELA mediated upregulation of RELB. Taken together, we provide computational and experimental support for interdependence between the F-actin network and RELA translocation dynamics in PDAC.

2024-10-25 | GSE268743 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data