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Effects of PCB 52 Exposure Via Sub-Acute Nose-Only Inhalation on Gene Expression in Livers of Adolescent Rats

ABSTRACT: Effects of PCB 52 Exposure Via Sub-Acute Nose-Only Inhalation on Gene Expression in Livers of Adolescent Rats

PROVIDER: PRJNA1073423 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27871600_1.fastq.gz	Fastqsanger.gz
	SRR27871600_2.fastq.gz	Fastqsanger.gz
	SRR27871601_1.fastq.gz	Fastqsanger.gz
	SRR27871601_2.fastq.gz	Fastqsanger.gz
	SRR27871602_1.fastq.gz	Fastqsanger.gz

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Effects of PCB 52 Exposure Via Sub-Acute Nose-Only Inhalation on Gene Expression in Livers of Adolescent Rats

Project description:Polychlorinated biphenyls (PCBs) are persistent environmental toxicants that pose a variety of health risks in humans. PCB 52 has been found in the indoor air of schools where adolescent students and staff are being actively exposed. This study examined the livers of adolescent Sprague-Dawley rats after sub-acute exposure to PCB 52 via nose-only inhalation. Rats were exposed for 4 hours daily for 28 consecutive days. RNA extracted from both male and female livers were submitted for RNA sequencing to compare the effects of PCB 52 on the expression of genes in the liver.

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Effects of PCB 52 Exposure Via Sub-Acute Nose-Only Inhalation on Gene Expression in Fat Depots of Adolescent Rats

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Effects of PCB 52 Exposure Via Sub-Acute Nose-Only Inhalation on Gene Expression in Fat Depots of Adolescent Rats

Project description:Effects of PCB 52 Exposure Via Sub-Acute Nose-Only Inhalation on Gene Expression in Fat Depots of Adolescent Rats

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Project description:Banned from mass production, polychlorinated biphenyls (PCBs) still pose a neurological health threat decades later. PCB52, a volatile compound, has been found in the indoor air of schools where adolescent students and staff are exposed. The adolescent brain is vulnerable and highly influenced by the environment around it. This study used adolescent Sprague-Dawley rats to determine the neurological effects of a subacute (28-day) PCB52 inhalation exposure. Rats were exposed 4 h a day for 28 consecutive days with neurobehavioral tests conducted during the last 5 days of exposure. Based on the data including brain weights, PCB52 and metabolite levels, gene expression in the striatum and cerebellum, and neurobehavioral tests (Y-maze, HBT, OFT, and EPM); a subacute inhalation of PCB52 results in sex-specific differences in response to exposure. Our results indicate multilevel PCB52 influence that is different in adolescent males and females; from gene expression to downstream innate mechanisms driving behavior.

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