Project description:Goal: We employed RNA-seq to identify targets of regulation of the Candida albicans transcription regulator CUP9. The cup9 deletion mutant strain displays increased fitness in a mouse model of oropharyngeal candidiasis.
Project description:Inventory of ABC transporters of Candida albicans shows presence of large no of ABC transporters in its genome.The large no of such protein presence suggested that these proteins may involve in various functions.To know involvement of PM ABC transporter orf19.3120 in different physiological roles transcriptional profiling have been peformed and compared between WT(SC5314) Candida albicans cells vs orf19.3120 knockout cells after 6hrs growth of culture.The assay as peformed in biological duplicate sample.
