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Iron metabolism in a mouse model of hepatocellular carcinoma

ABSTRACT: Iron metabolism in a mouse model of hepatocellular carcinoma

PROVIDER: PRJNA1075082 | ENA |

REPOSITORIES: ENA

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Iron metabolism in a mouse model of hepatocellular carcinoma

Project description:Background & Aims: Liver cancer is the sixth most frequently diagnosed type of cancer and the third leading cause of cancer-related mortality worldwide. One of the most frequently effected pathways in liver carcinoma is the p53 signalling pathway. Emerging evidence indicates that deregulation of p53 leads to several metabolic disorders that are pivotal during cancer progression. Methods: We induced chronic liver disease and subsequent liver carcinoma formation by chronic injection of CCl4 (16 weeks treatment) in p53f/f and p53LKO mice. We characterized major differences between HCC from p53f/f and HCC from p53LKO mice. In addition, we characterized differences between HCC and ICC, both from p53LKO mice. Results: We show that Conclusions: Dysregulation of Notch signaling is involved in tumor differentiation. Loss of Rbpj triggers the formation of combined HCC-iCCA which is associated by a pro-tumorigenic environment. Results: We show that all liver cancers that develop on a p53-deficient background have an iron-poor phenotype with a “low hepcidin and high Tfr1” signature, while iron deficiency at the systemic level is restricted to female mice. In addition to iron, liver tumorigenesis correlated with significant deficits of selenium, zinc and manganese, accompanied by changes in their key metabolic players. Conclusions: Our work demonstrates a pivotal role for p53 in a complex network controlling tumor development and micronutrient metabolism, locally in the liver cancers, and at a systemic level along with highlighting sex-specific differences underlying liver cancer development and the distribution of trace elements.

2025-01-22 | GSE255470 | GEO

Hepatocellular carcinoma mouse model

Project description:Txnip deficient mice with hepatocellular carcinoma Keywords: repeat sample

2005-01-07 | GSE2127 | GEO

Atosiban harness hepatocellular carcinoma progression in human organoid model

Project description:Atosiban harness hepatocellular carcinoma progression in human organoid model

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Galectin-9 suppresses growth of hepatocellular carcinoma in vivo

Project description:Galectin-9 suppresses growth of Li-7 cells, a cell line of human hepatocellular carcinoma, in xenograft model analysis. Micro RNA expression in xenografts of Li-7 cells, a cell line of hepatocellular carcinoma, with or without administration of galectin-9 were assessed.

2015-03-01 | E-GEOD-55666 | biostudies-arrayexpress

Exome sequencing of lemur hepatocellular carcinoma

Project description:Exome sequencing of lemurs with hepatocellular carcinoma

2022-03-21 | PRJEB51774 | EVA

Intracellular labile iron is a key regulator of hepcidin expression and iron metabolism

Project description:Liver iron overload can induce hepatic expression of hepcidin and regulates iron metabolism. However, the mechanism of iron regulating iron metabolism remains known. Intracellular labile iron represents the nonferritin-bound, redox-active iron which is transitory and serves as a crossroad of cell iron metabolism. The role of intracellular labile iron played in iron metabolism has largely been elucidated. Here we show that intracellular labile iron of hepatocytes has dual function in iron metabolism. It can induce hepatocytes expressing hepcidin via ER stress induced transcription factors on the one hand, on the other hand stimulate BMP2 and BMP6 expression of liver sinusoidal endothelial cells (LSECs) though TNFα secreted by hepatocytes to further regulate iron metabolism. Blockade of TNFα could dysregulate the iron metabolism during iron overload. Our findings reveal the important role of intracellular labile iron in iron metabolism and represent a novel way to modulate iron metabolism during iron overload.

2023-05-03 | GSE186655 | GEO

Human hepatocellular carcinoma

Project description:Spatial transcriptome on human hepatocellular carcinoma

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Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Project description:Hepatic iron overload is a risk factor for progression of hepatocellular carcinoma (HCC), although the molecular mechanisms underlying this association have remained unclear. We now show that the iron-sensing ubiquitin ligase FBXL5 is previously unrecognized oncosuppressor in liver carcinogenesis in mice. Hepatocellular iron overload evoked by FBXL5 ablation gives rise to oxidative stress, tissue damage, inflammation and compensatory proliferation in hepatocytes and to consequent promotion of liver carcinogenesis induced by exposure to a chemical carcinogen. The tumor-promoting effect of FBXL5 deficiency in the liver is also operative in a model of virus-induced HCC. FBXL5-deficient mice thus constitute the first genetically engineered mouse model of liver carcinogenesis induced by iron overload. Dysregulation of FBXL5-mediated cellular iron homeostasis was also found to be associated with poor prognosis in human HCC, implicating FBXL5 plays a significant role in defense against hepatocarcinogenesis.

2019-03-09 | GSE124370 | GEO

Transcription profiling of iron homeostasis in liver cancer

Project description:The study of gene expression profile of iron homeostasis-related genes using Affymetrix GeneChips in conjunction with the pathological assessment of hepatic iron content in hepatocellular carcinoma (HCC) samples offers a new strategy to understand the role of hepatic iron overload in hepatocarcinogenesis.

2007-01-10 | E-MEXP-84 | biostudies-arrayexpress

Comprehensive analysis of the miRNA profile between HBV-related Hepatocellular carcinoma (HBCC) and no HBV-related Hepatocellular carcinoma (HNCC)

Project description:To explore the miRNA expression profiles between HBV-related Hepatocellular carcinoma and no HBV-related Hepatocellular carcinoma To performe microarray analysis to detect the miRNA expression profiles between HBV-related Hepatocellular carcinoma and no HBV-related Hepatocellular carcinoma

2021-05-29 | GSE151441 | GEO

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