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Topical Ruxolitinib in the Treatment of Necrobiosis Lipoidica: A Prospective, Open-Label Study

ABSTRACT: Topical Ruxolitinib in the Treatment of Necrobiosis Lipoidica: A Prospective, Open-Label Study

PROVIDER: PRJNA1075144 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27935200_1.fastq.gz	Fastqsanger.gz
	SRR27935200_2.fastq.gz	Fastqsanger.gz
	SRR27935201_1.fastq.gz	Fastqsanger.gz
	SRR27935201_2.fastq.gz	Fastqsanger.gz
	SRR27935202_1.fastq.gz	Fastqsanger.gz

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Topical Ruxolitinib in the Treatment of Necrobiosis Lipoidica: A Prospective, Open-Label Study

Project description:Necrobiosis Lipoidica (NL) is a rare granulomatous disease. There are few effective treatments for NL. We sought to investigate the efficacy and safety of the JAK 1/2 inhibitor, ruxolitnib, in the treatment of NL and identify biomarkers associated with disease and treatment response. We conducted an open-label, phase 2 study of ruxolitinib in 12 patients with NL. We performed transcriptomic analysis of tissue samples pre- and post-treatment. At week 12, the mean NL lesion score decreased by 58.2% (SD 28.7%, P=0.003). Transcriptomic analysis demonstrated enrichment of type I and type II interferon pathways in baseline disease. Weighted Gene Co-expression Network Analysis (WGCNA) demonstrated post-treatment changes in interferon pathways with key hub genes IFNG and STAT1. Limitations include small sample size and a study group limited to patients with <10% BSA. In conclusion, ruxolitinib is an effective treatment for NL and targets the key pathogenic mediators of disease.

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Treatment of established mouse AA with topical JAK inhibitors

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