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Effect of depletion of Igf2bp3 on gene expression during VSV infection in RAW 264.7 cells and mice PMs

ABSTRACT: Effect of depletion of Igf2bp3 on gene expression during VSV infection in RAW 264.7 cells and mice PMs

PROVIDER: PRJNA1076148 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27957050_1.fastq.gz	Fastqsanger.gz
	SRR27957050_2.fastq.gz	Fastqsanger.gz
	SRR27957051_1.fastq.gz	Fastqsanger.gz
	SRR27957051_2.fastq.gz	Fastqsanger.gz
	SRR27957052_1.fastq.gz	Fastqsanger.gz

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Effect of depletion of Igf2bp3 on gene expression during VSV infection in RAW 264.7 cells and mice PMs

Project description:N6-methyladenosine (m6A) modification is the most abundant RNA modification in both host mRNA and viral RNA transcripts. Dynamic regulation and recognition of m6A modification widely participate in post-transcriptional regulation of many biological processes. This project aims to define the regulation role of IGF2BP3, a m6A recognition protein, in viral infection, especially in RNA viral infection. In this study, the transcriptomes of Vesicular stomatitis virus (VSV)-infected WT/Igf2bp3-KO RAW264.7 cells and mouse peritoneal macrophages (PMs) were analyzed, suggesting the role of IGF2BP3 in the host's innate immune responses during viral infection and enhancement.

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