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CAMKV inhibitor, OTSSP167 induces transcriptomic changes in NGP cells

ABSTRACT: CAMKV inhibitor, OTSSP167 induces transcriptomic changes in NGP cells

PROVIDER: PRJNA1076169 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27963038_1.fastq.gz	Fastqsanger.gz
	SRR27963038_2.fastq.gz	Fastqsanger.gz
	SRR27963039_1.fastq.gz	Fastqsanger.gz
	SRR27963039_2.fastq.gz	Fastqsanger.gz
	SRR27963040_1.fastq.gz	Fastqsanger.gz

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CAMKV inhibitor, OTSSP167 induces transcriptomic changes in NGP cells

Project description:To investigate the effect of CAMKV inhibitor, OTSSP167, on NB cell proliferation and delineate the mechanisms of CAMKV-mediated pathway inhibition in NB. We treated human neuroblastoma cell line, NGP with OTSSP167 and performed gene expression profiling analysis using data obtained from RNA-seq.

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Project description:To investigate the effect of CAMKV knockdown on transcriptomic profiling in neuroblastoma and delineate the role of CAMJV in neuroblastoma growth. We knockdowned the gene exprssion of CAMKV in NGP cells and performed gene expression profiling analysis using data obtained from RNA-seq.

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Human TNBC Cells 48h Treatment with OTSSP167 MELK Inhibitor vs. DMSO Control

Project description:Microarray comparing TNBC cells treated for 48 hours with OTSSp167 MELK Inhibitor and control (DMSO) Two-condition arrays: MDA-MB-231 cells were treated with either 4.5nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 48h. Two biological replicates, one per array, with a dye swap (technical replicate).

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Transcriptome profiling of drug resistant cell lines (NGP-127).

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Human TNBC Cells 72h Treatment with 45nM OTSSP167 MELK Inhibitor vs. DMSO Control

Project description:Microarray comparing TNBC cells treated for 72 hours with OTSSP167 MELK Inhibitor and control (DMSO) Two-condition arrays: MDA-MB-231 cells were treated with either 45nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 72h. Two biological replicates, one per array, with a dye swap (technical replicate).

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