Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TGF-β and RAS jointly unmask primed enhancers to drive metastasis

ABSTRACT: TGF-β and RAS jointly unmask primed enhancers to drive metastasis

PROVIDER: PRJNA1077379 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27996700_1.fastq.gz	Fastqsanger.gz
	SRR27996700_2.fastq.gz	Fastqsanger.gz
	SRR27996701_1.fastq.gz	Fastqsanger.gz
	SRR27996701_2.fastq.gz	Fastqsanger.gz
	SRR27996702_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 150

Similar Datasets

TGF-β and RAS jointly unmask primed enhancers to drive metastasis (DRIPc-seq)

Project description:TGF-β and RAS jointly unmask primed enhancers to drive metastasis (DRIPc-seq)

| PRJNA1077394 | ENA

TGF-β and RAS jointly unmask primed enhancers to drive metastasis (ChIP-Seq)

Project description:TGF-β and RAS jointly unmask primed enhancers to drive metastasis (ChIP-Seq)

| PRJNA1077390 | ENA

TGF-β and RAS jointly unmask primed enhancers to drive metastasis (ATAC-Seq)

Project description:TGF-β and RAS jointly unmask primed enhancers to drive metastasis (ATAC-Seq)

| PRJNA1077391 | ENA

TGF-β and RAS jointly unmask primed enhancers to drive metastasis (Mnase-Seq)

Project description:TGF-β and RAS jointly unmask primed enhancers to drive metastasis (Mnase-Seq)

| PRJNA1077393 | ENA

TGF-β and RAS jointly unmask primed enhancers to drive metastasis (RNA-Seq)

Project description:TGF-β and RAS jointly unmask primed enhancers to drive metastasis (RNA-Seq)

| PRJNA1077392 | ENA

TGF-β and RAS jointly unmask primed enhancers to drive metastasis (RNA-Seq)

Project description:Epithelial-to-mesenchymal transitions (EMTs) and extracellular matrix (ECM) remodeling are distinct yet important processes during carcinoma invasion and metastasis. TGF-β and RAS, signaling through SMAD and RAS-responsive element-binding protein 1 (RREB1), jointly trigger expression of EMT and fibrogenic factors as two discrete arms of a common transcriptional response in carcinoma cells. Here we demonstrate that both arms form a program for lung adenocarcinoma pulmonary metastasis and identify chromatin determinants tying the expression of the constituent genes to TGF-β and RAS dual inputs. RREB1 binds near H4K16ac histone marks and histone H2A.Z-loaded nucleosomes at enhancers in the fibrogenic genes IL11, PDGFB, and HAS2 and the EMT transcription factor SNAI1, priming these enhancers for activation by a SMAD4-INO80 nucleosome remodeling complex in response to TGF-β. These regulatory properties set the fibrogenic EMT program apart from RAS-independent TGF-β gene responses and illuminate the operation and vulnerabilities of a transcriptional program that promotes metastatic outgrowth.

2024-09-26 | GSE256019 | GEO

TGF-β and RAS jointly unmask primed enhancers to drive metastasis (Mnase-Seq)

2024-09-26 | GSE256018 | GEO