Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Henricia sp. BOLD:AAB3569

ABSTRACT: Henricia sp. BOLD:AAB3569 (seastar) genomic and transcriptomic data

PROVIDER: PRJNA1079401 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28089719_subreads.fastq.gz	Fastqsanger.gz
	SRR28089720_subreads.fastq.gz	Fastqsanger.gz
	SRR28089721_1.fastq.gz	Fastqsanger.gz
	SRR28089721_2.fastq.gz	Fastqsanger.gz
	SRR28089722_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Henricia sp. BOLD:AAB3569

Project description:Henricia sp. BOLD:AAB3569 (seastar)

| PRJNA1079400 | ENA

Henricia sp. BOLD:AAB3569

Project description:Henricia sp. BOLD:AAB3569 (seastar) genome assembly, eaHenAAB3569, principal haplotype

| PRJNA1081154 | ENA

Henricia leviuscula

Project description:Henricia leviuscula (Pacific blood star) genomic and transcriptomic data

| PRJNA1131420 | ENA

Henricia

Project description:Henricia sp. overview

| PRJNA1079487 | ENA

Henricia leviuscula

Project description:Henricia leviuscula overview

| PRJNA1131504 | ENA

Henricia leviuscula

Project description:Henricia leviuscula (Pacific blood star), eaHenLevi1

| PRJNA1131404 | ENA

Henricia leviuscula

Project description:Henricia leviuscula Transcriptome or Gene expression

| PRJNA299415 | ENA

Interaction with ribosomal proteins accompanies ER stress-induction of the anticancer metallodrug BOLD-100/KP1339

Project description:The ruthenium-based anticancer agent BOLD-100/KP1339 has shown promising results in several in vitro and in vivo tumour models, as well as in early clinical trials. However, its mode of action remains to be fully elucidated. Recent evidence identified ER stress-induction and concomitant down-modulation of HSPA5 (GRP78) as key drug effects. By exploiting the naturally formed adduct between BOLD-100 and human serum albumin as an immobilization strategy, we were able to perform target profiling experiments that revealed the ribosomal proteins RPL10, RPL24 and the transcription factor GTF2I as potential interactors of this ruthenium(III) anticancer agent. Integrating these findings with proteomic profiling and transcriptomic experiments supported ribosomal disturbance and concomitant induction of endoplasmic reticulum (ER) stress. The formation of poly-ribosomes and ER swelling of treated cancer cells by electron microscopy validated this finding. Thus, the direct interaction of BOLD-100 with ribosomal proteins seems to accompany ER stress-induction and modulation of GRP78 in cancer cells.

2021-06-01 | PXD022449 | Pride

Project description:WTCCC2 project Schizophrenia (SP) samples

| EGAD00010000262 | EGA

Henricia longispina aleutica strain:Echinodermata | isolate:Henricia longispina aleutica | breed:Animal | cultivar:Asteroidea

Project description:Henricia longispina aleutica strain:Echinodermata | isolate:Henricia longispina aleutica | breed:Animal | cultivar:Asteroidea Raw sequence reads

| PRJNA1073699 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data