Project description:4 cancer cell lines were treated with T-025 for 6 hours T-025 is a novel small molecule inhibitor of CLK. CLK is a kinase that regulates pre-mRNA splicing.
Project description:Microarray studies were conducted with RNA isolated from vehicle- or PNB-028- treated MAC-16 colon cancer xenograft tumors (n=3/group). PNB-028 significantly regulated over 1400 genes compared to vehicle-treated samples with approximately 450 genes up-regulated and 1100 genes down-regulated by 1.5 fold or greater.