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New therapy for colorectal cancer targeting cancer metabolism through serotonin receptor HTR2B

ABSTRACT: New therapy for colorectal cancer targeting cancer metabolism through serotonin receptor HTR2B

PROVIDER: PRJNA1084766 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28242622_1.fastq.gz	Fastqsanger.gz
	SRR28242622_2.fastq.gz	Fastqsanger.gz
	SRR28242623_1.fastq.gz	Fastqsanger.gz
	SRR28242623_2.fastq.gz	Fastqsanger.gz
	SRR28242624_1.fastq.gz	Fastqsanger.gz

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New therapy for colorectal cancer targeting cancer metabolism through serotonin receptor HTR2B

Project description:Serotonin is important material in our body. 5-HT is synthesized by TPH1 starting with tryptophan and this compound exists on colorectal cancer. And serotonin combines with various receptors to conduct the metabolic pathway in colorectal cancer. Each receptor relates with various metabolism, such as lipid metabolism, growth, immunity, etc. In this way, medicine which inhibits these receptors can expect for therapy of colorectal cancer. Especially HTR 2B has correlation with growth factor and using the inhibitor of HTR2B, SB204741, can have effect on metabolic pathway in colorectal cancer. So, we set the hypothesis that HTR2B antagonist can have negative effect on growth of colorectal cancer.

2024-03-12 | GSE260979 | GEO

Cancer anorexia: the role of serotonin in hypothalamic resistance of the neuropeptide Y system [A358_GEO_hypocells]

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Project description:Analysis of Bxpc-3 cells treated with serotonin under metabolic stress induced by serum deprivation. Serotonin (5-HT), a well-known neuromodulator with both neurotransmitter and neuroendocrine functions, is also involved in tumorigenesis. Results provide insight into molecular basis of serotonin in pancreatic cancer.

2016-05-12 | GSE81355 | GEO

Transcriptomic analysis of the mouse mammary gland reveals new insights for the role of serotonin in lactation

Project description:Serotonin in the mammary gland is known to regulate processes such as calcium homeostasis, tight junction permeability, and milk protein gene expression. The objective of this study was to discover novel genes, pathways and functions which serotonin modulates during lactation. The rate-limiting enzyme in the synthesis of non-neuronal serotonin is tryptophan-hydroxylase (TPH1). Therefore, we used TPH1 knock-out mice dams (serotonin deficient) and compared them to wild-type dams and also Tph1 deficient dams injected daily with 5-HTP. Mammary gland tissues were collected on day 10 of lactation and then analyzed by RNA sequencing. Genome-wide gene expression profiles of 12 mouse mammary gland samples were evaluated using RNA sequencing; these 12 samples belong to wild-type dams (WT; n = 4), Tryptophan hydroxylase (Tph1) knock-out dams (KO; Tph1 deficient; n = 4), and Tph1 deficient dams injected daily with 5-HTP (RC; n = 4). Mammary tissues were collected on day 10 of lactation and then underwent RNA extraction, library generation, and subsequent sequencing.

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