Phodopus sungorus
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ABSTRACT:
PROVIDER: PRJNA108477 | ENA |
REPOSITORIES: ENA
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Project description:The mechanism(s) involved in the regulation of the seasonal-appropriate body weight of the Siberian hamster is currently unknown. We have identified photoperiodically regulated genes including VGF in a sub-region of the arcuate nucleus termed the dorsomedial posterior arcuate (dmpARC). Gene expression changes in this nucleus so far account for a significant number of those reported as photoperiodically regulated and are therefore likely to contribute to seasonal physiological responses of the hamsters. The present study was conducted to identify additional genes expressed in the dmpARC regulated by photoperiod that could be involved in regulating the activity of this nucleus with respect to seasonal physiology of the Siberian hamster. Using laser capture microdissection coupled with a microarray analysis and a candidate gene approach, we have identified in the dmpARC several photoperiodically regulated genes that are known to have roles in secretory and intracellular signaling pathways. These include secretogranin III (SgIII) and SgVI (secretory pathway), melanocortin 3 receptor (MC3-R) and serotonin (5-HT) receptors 2A and 7 (signaling pathway), all of which increase in expression in short photoperiod. The spatial relationship between receptor signaling and potential secretory pathways was investigated by dual in situ hybridization, which revealed that 5-HT2A and 5-HT7 receptors are expressed in neurons expressing VGF mRNA and that a sub-population (approximately 40%) of these neurons express MC3-R. These gene expression changes in dmpARC neurons may reflect the functional requirement of these neurons for seasonal physiology responses of the hamster Samples were taken from 10 individual animals, 5 of which had lived under a short day (SD) photoperiod, the other 5 under a long day (LD) photoperiod. Each hybridisation compared a LD sample (labelled with Cy5) with a SD sample (labelled with Cy3).
2010-05-15 | E-GEOD-10278 | biostudies-arrayexpress
Project description:The mechanism(s) involved in the regulation of the seasonal-appropriate body weight of the Siberian hamster is currently unknown. We have identified photoperiodically regulated genes including VGF in a sub-region of the arcuate nucleus termed the dorsomedial posterior arcuate (dmpARC). Gene expression changes in this nucleus so far account for a significant number of those reported as photoperiodically regulated and are therefore likely to contribute to seasonal physiological responses of the hamsters. The present study was conducted to identify additional genes expressed in the dmpARC regulated by photoperiod that could be involved in regulating the activity of this nucleus with respect to seasonal physiology of the Siberian hamster. Using laser capture microdissection coupled with a microarray analysis and a candidate gene approach, we have identified in the dmpARC several photoperiodically regulated genes that are known to have roles in secretory and intracellular signaling pathways. These include secretogranin III (SgIII) and SgVI (secretory pathway), melanocortin 3 receptor (MC3-R) and serotonin (5-HT) receptors 2A and 7 (signaling pathway), all of which increase in expression in short photoperiod. The spatial relationship between receptor signaling and potential secretory pathways was investigated by dual in situ hybridization, which revealed that 5-HT2A and 5-HT7 receptors are expressed in neurons expressing VGF mRNA and that a sub-population (approximately 40%) of these neurons express MC3-R. These gene expression changes in dmpARC neurons may reflect the functional requirement of these neurons for seasonal physiology responses of the hamster
2008-11-29 | GSE10278 | GEO
Project description:Prolactin (PRL) is a multifunctional hormone involved in diverse physiological processes, including lactation, reproduction, growth, and renal function. However, its effects on kidney morphology in seasonal mammals remain largely unexplored. The Siberian hamster (Phodopus sungorus), a seasonally breeding species, exhibits distinct physiological adaptations in response to photoperiod-driven changes in prolactin levels. Previous studies have demonstrated that PRL treatment significantly increases kidney mass, yet the underlying molecular mechanisms remain unclear. This study aimed to investigate the impact of PRL on kidney morphology and the associated molecular pathways. Histological analysis using Hematoxylin and Eosin (H&E) staining revealed that PRL treatment significantly increased convoluted tubule width (CTW). To elucidate the molecular basis of these morphological changes, transcriptome analysis was performed, identifying 19 significantly enriched pathways that were negatively correlated with CTW. These findings provide novel insights into the role of PRL in regulating seasonal kidney morphology and highlight key molecular pathways involved in this process.Our results contribute to a deeper understanding of PRL’s role in renal adaptations to seasonal changes, paving the way for future research into the endocrine regulation of kidney structure and function in seasonal mammals.
2025-03-31 | GSE292481 | GEO
Project description:Different developmental trajectories of ovaries in Siberian hamsters raised in long and short day lengths
| PRJNA219204 | ENA
Project description:Phodopus sungorus Genome sequencing and assembly
| PRJNA318271 | ENA
Project description:Phodopus sungorus whole genome sequencing and assembly
| PRJNA1029001 | ENA
Project description:Phodopus sungorus Transcriptome or Gene expression
| PRJNA360070 | ENA
Project description:Papillomaviruses (PVs) are considered highly species-specific with cospeciation as the main driving force in their evolution. However, a recent increase in the available PV genome sequences has revealed inconsistencies in virus-host phylogenies, which could be explained by adaptive radiation, recombination, host-switching events and a broad PV host range. Unfortunately, with a relatively low number of animal PVs characterized, understanding these incongruities remains elusive. To improve knowledge of biology and the spread of animal PV, we collected 60 swabs of the anogenital and head and neck regions from a healthy colony of 30 Roborovski hamsters (Phodopus roborovskii) and detected PVs in 44/60 (73.3%) hamster samples. This is the first report of PV infection in Roborovski hamsters. Moreover, Phodopus sungorus papillomavirus type 1 (PsuPV1), previously characterized in Siberian hamsters (Phodopus sungorus), was the only PV detected in Roborovski hamsters. In addition, after a detailed literature search, review and summary of published evidence and construction of a tanglegram linking the cladograms of PVs and their hosts, our findings were discussed in the context of available knowledge on PVs described in at least two different host species.
| S-EPMC8145573 | biostudies-literature