Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Sebaceous Neoplasm Tissue Study, 20190101

ABSTRACT: Sebaceous Neoplasm Tissue Study, 20190101

PROVIDER: PRJNA1085410 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Sebaceous Neoplasm Tissue Study, 20190101

Project description:Sebaceous Neoplasm Tissue Study, 20190101

| PRJNA1085409 | ENA

Identification of genes involved in sebaceous gland carcinoma of the eyelid

Project description:Sebaceous gland carcinoma is the frequent malignant tumor of the eyelid. However, there is limited understanding of how altered gene expression of sebaceous gland carcinoma of the eyelid related to the pathogenesis. In this study, to identify genes involved in sebaceous gland carcinoma of the eyelid, global-scale gene expression analysis was carried out using a GeneChip® system.

2019-01-25 | GSE125582 | GEO

Lipid metabolizing enzymes differ between preputial gland sebocytes and sebaceous gland sebocytes

Project description:Due to limited model systems for sebaceous glands we investigated potential suitability of preputial glands as model for sebaceous glands. We performed single-cell sequencing of murine preputial glands and back skin biopsies. This study revealed striking differences in lipid metabolizing enzyme expression and differentiation pathways found in sebocytes of the different tissues.

2022-01-24 | GSE185268 | GEO

Integrated whole-exome and transcriptome sequencing indicated dysregulation of cholesterol metabolism in eyelid sebaceous gland carcinoma

Project description:To identify the molecular background of eyelid sebaceous gland carcinomas (SCs), the integrated whole-exome sequencing and transcriptome sequencing for five eyelid SCs were conducted in this study.

2023-02-15 | GSE219205 | GEO

Sebaceous gland atrophy in psoriasis: An explanation for psoriatic alopecia?

Project description:In a transcriptome study of psoriatic (PP) vs. normal (NN) skin, we found a co-expressed gene module (N5) enriched 11.5-fold for lipid biosynthetic genes. We also observed fewer visible hairs in PP skin, compared to uninvolved (PN) or NN skin (p<0.0001). To ask whether these findings might be due to abnormalities of the pilosebaceous unit, we carried out 3D morphometric analysis of paired PP and PN biopsies. Sebaceous glands (SG) were markedly atrophic in PP vs. PN skin (91% average reduction in volume, p=0.031). Module N5 genes were strongly downregulated in PP vs. NN skin (fold-change [FC] < 0.25, 44.4-fold), and strongly up-regulated in sebaceous hyperplasia (SH, FC > 4, 54.1-fold). The intersection of PP-downregulated and SH-upregulated gene lists generated a gene expression signature consisting solely of module N5 genes, whose expression in PP vs. NN skin was inversely correlated with the signature of IL17-stimuated keratinocytes. Despite loss of visible hairs, morphometry identified elongated follicles in PP vs. PN skin (average 1.7 vs. 1.2 Jm, p=0.020). These results document SG atrophy in non-scalp psoriasis, identify a cytokine-regulated set of SG signature genes, and suggest that loss of visible hair in PP skin may result from abnormal SG function. Gene expression was compared between sebaceous hyperplasia lesions (n = 5) and normal skin (n = 3) from control subjects.

2016-06-02 | E-GEOD-82140 | biostudies-arrayexpress

Gene Expression of Serous Cystic Neoplasm of the Pancreas Tissues

Project description:Serous (cystic) neoplasm (SCN) of the pancreas is usually benign cystic neoplasm and has unique biological characteristics that are different from those found in the normal pancreatic tissue or pancreatic ductal adenocarcinoma (PDAC) tissue. In order to investigate molecular mechanisms involved in the unique biological phenotypes of, we compared gene expression profiles of SCN tissues with those of normal pancreatic tissues or those of PDAC tissues.

2024-05-06 | GSE173969 | GEO

High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Novel Marker Genes and Decodes Sebocyte Differentiation

Project description:The sebaceous gland is essential for skin homeostasis by producing sebum to lubricate and protect the skin. However, its cellular and molecular mechanisms in humans remain poorly understood as most studies have been conducted in mouse models. This study provides a comprehensive molecular analysis of the human sebaceous gland, focusing on cellular interactions, novel gene markers, and sebocyte differentiation. By integrating Stereo-seq spatial transcriptomics, single-cell RNA sequencing, and validation though MERFISH, we identified four distinct stages of sebocyte differentiation, each characterized by unique gene signatures. These results reveal sebocyte differentiation as a dynamic and complex process. Our findings enhance the understanding of sebaceous gland biology and provide a valuable reference for future research and the development of therapies for sebaceous gland-related disorders, including acne.

2025-04-23 | GSE292156 | GEO

High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Novel Marker Genes and Decodes Sebocyte Differentiation [MERFISH]

2025-04-23 | GSE292394 | GEO

Transcriptomic comparison between human epidermis and human sebaceous glands

Project description:Analysis of gene expression profiling of human epidermis and sebaceous glands. Skin samples were obtained from 5 healthy individuals undergoing plastic surgery

2018-04-30 | GSE108290 | GEO

Sebaceous gland progenitor cell RNAseq during morphogenesis and steady state homeostasis

Project description:Laser capture microdissection enriched for sebaceous gland basal cells at P4, P10, P30

2019-07-15 | GSE126491 | GEO