Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA108613 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Identification of genes responsive to hyperthermia in human leukemia U937 cells
| PRJNA110103 | ENA
Project description:The rationale underlying hyperthermia is the fact that temperatures over 42.5˚C are highly cytotoxic to tumor cells. On the other hand, although mild hyperthermia at a range from 39 to 41˚C alone did not induce cytotoxicity in tumor cells, mild hyperthermia is reported to show a synergism with radiotherapy and anti-cancer drugs. Here, the effects of mild hyperthermia (41˚C for 30 min) on the gene expression in human lymphoma U937 cells were investigated using by an Affymetrix GeneChip system. Although the cells treated with the mild hyperthermia did not induce apoptosis, a significant increase in protein levels of heat shock proteins, Hsp40 and Hsp70, was observed following activation of heat shock factor-1. At 3 h post-treatment, 938 probe sets that were differentially expressed by >1.5-fold were identified. Keywords: mild hyperthermia, gene expression, Human lymphoma U937 cell
2008-01-03 | GSE10043 | GEO
Project description:Identification of genes responsive to ultrasound in human leukemia U937 cells
| PRJNA108333 | ENA
Project description:Identification of genes responsive to mild hyperthermia in human skin normal fibroblast Hs68 cells
| PRJNA170527 | ENA
Project description:Identification of genes responsive to mild hyperthermia in human normal fibroblast OUMS-36 cells
| PRJNA170530 | ENA
Project description:Identification of genes responsive to mild hyperthermia in human cervical squamous cell carcinoma HeLa cells
| PRJNA187084 | ENA
Project description:Identification of genes responsive to mild hyperthermia in human oral squamous cell carcinoma HSC-3 cells
| PRJNA187926 | ENA
Project description:The rationale underlying hyperthermia is the fact that temperatures over 42.5ËC are highly cytotoxic to tumor cells. On the other hand, although mild hyperthermia at a range from 39 to 41ËC alone did not induce cytotoxicity in tumor cells, mild hyperthermia is reported to show a synergism with radiotherapy and anti-cancer drugs. Here, the effects of mild hyperthermia (41ËC for 30 min) on the gene expression in human lymphoma U937 cells were investigated using by an Affymetrix GeneChip system. Although the cells treated with the mild hyperthermia did not induce apoptosis, a significant increase in protein levels of heat shock proteins, Hsp40 and Hsp70, was observed following activation of heat shock factor-1. At 3 h post-treatment, 938 probe sets that were differentially expressed by >1.5-fold were identified. Experiment Overall Design: U937 cells, a human lymphoma cell line, were treated with mild hyperthermia (41ËC for 30 min) and followed by incubation for 3 h at 37°C. Non-treated cells were served as control. Total RNA samples were prepared from the cells. Gene expression was analyzed by an Affymetrix GeneChip® system with Human Expression Array U133A which was spotted with 22,283 probe sets. Sample preparation for array hybridization was carried out as described in the manufactureâs instructions.
2008-06-11 | E-GEOD-10043 | biostudies-arrayexpress
Project description:Identification of genes responsive to the combination of Sonazoid and ultrasound in human leukemia U937 cells
| PRJNA117237 | ENA
Project description:Identification of genes responsive to paeoniflorin, a heat shock protein-inducing compound, in human leukemia U937 cells
| PRJNA101155 | ENA