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Soma-to-Germline miRNA inheritance via Yolk Promotes Stress Resilience in Progeny [mRNA]

ABSTRACT: Soma-to-Germline miRNA inheritance via Yolk Promotes Stress Resilience in Progeny [mRNA]

PROVIDER: PRJNA1086515 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28292579.fastq.gz	Fastqsanger.gz
	SRR28292580.fastq.gz	Fastqsanger.gz
	SRR28292581.fastq.gz	Fastqsanger.gz
	SRR28292582.fastq.gz	Fastqsanger.gz
	SRR28292583.fastq.gz	Fastqsanger.gz

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Soma-to-Germline miRNA inheritance via Yolk Promotes Stress Resilience in Progeny [mRNA]

Project description:At the onset of reproduction, oviparous animals synthesize large amounts of yolk in somatic tissues to provide lipids and other nutrients to their progeny. However, whether the yolk transports other types of molecules, such as RNAs with gene regulatory functions, remains largely unexplored. Here, we have biochemically purified the yolk in the nematode Caenorhabditis elegans and show it contains microRNAs (miRNAs). We provide evidence that the yolk transports such miRNAs from the mother’s intestine to the embryos via the lipoprotein yolk receptor RME-2. These yolk-enriched miRNAs inherited by the embryos regulate the transcriptomes of developing larvae. Moreover, environmental stresses and maternal age modulate the transfer of yolk-enriched miRNAs, providing stress resilience benefits to progeny. This discovery establishes a novel paradigm in intergenerational gene regulation, where the gut-germline axis orchestrates the transmission of environmental cues through yolk-enriched miRNAs. Our work reveals a new mechanism underlying the soma-to-germline transfer of epigenetic information in animals.

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Soma-to-Germline miRNA inheritance via Yolk Promotes Stress Resilience in Progeny [small RNA]

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Soma-to-Germline miRNA inheritance via Yolk Promotes Stress Resilience in Progeny [small RNA]

Project description:Soma-to-Germline miRNA inheritance via Yolk Promotes Stress Resilience in Progeny [small RNA]

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Project description:Transgenerational inheritance of acquired traits/characteristics from ancestors is believed to play important roles in evolution, as well as health problems/symptoms not due to “classical genetic inheritance”. However, the central enigma, such as how the acquired transgenerational characteristics are developed, and how the acquired traits are transmitted from generations to generations of offspring, largely remained veiled. In this study, we used C elegans as a model system and provide evidence that the dynamic of H3K27me3 as a hallmark and regulator for the gut-mediated transgenerational inheritance of acquired traits. Further, we demonstrate that yolk proteins guide the establishment of the acquired epigenetic imprints in soma, as well as determines the transgenerational inheritance of epigenetic imprints and subsequent acquired behavior in offspring by maternal provision. Taken together, our findings support that yolk proteins both function as a systemic “non-nuclear factor” for establishing the somatic epigenetic imprints and as a “cargo” to transmit acquired epigenetic information to the subsequent generations through oocytes.

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Project description:To define what genes are predominantly or specifically expressed in either soma or germline in C. elegans adults, total RNA was extracted from germline-less glp-4 mutant animals or from dissected gonads, respectively. Total RNA sequencing was peformed in duplicates. Four samples in total.

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