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Limb connective tissue is organized in a continuum of promiscuous fibroblast identities during development

ABSTRACT: Limb connective tissue is organized in a continuum of promiscuous fibroblast identities during development

PROVIDER: PRJNA1087332 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28331448_1.fastq.gz	Fastqsanger.gz
	SRR28331448_2.fastq.gz	Fastqsanger.gz
	SRR28331449_1.fastq.gz	Fastqsanger.gz
	SRR28331449_2.fastq.gz	Fastqsanger.gz

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Limb connective tissue is organized in a continuum of promiscuous fibroblast identities during development

Project description:Although connective tissues play critical roles in development, our understanding of connective tissue fibroblast developmental programs lag behind that of other components of the musculoskeletal system mainly because fibroblasts are highly heterogeneous and poorly characterized. Combining single-cell RNA-sequencing-based strategies, including trajectory inference, and in situ hybridization analyses, we address the diversity of connective tissue fibroblasts and their developmental trajectories during chicken limb foetal development. We show that fibroblasts switch from a positional information to a lineage diversification program during their development. Muscle connective tissue and tendon contain several fibroblast populations that emerge asynchronously. In fine, these populations map to distinct layers, prefiguring the adult fibroblast layers. Populations that are close in transcriptional identity are found in neighboring layers. Altogether, we propose that the limb connective tissue is organised in a continuum of promiscuous fibroblasts identities, allowing for the robust and efficient connection of highly different tissues such as muscle, bone and skin.

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