Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: RNA-seq data from Caco-2 cells treated by Giardia intestinalis extracellular vesicles

PROVIDER: PRJNA1088188 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28349256_1.fastq.gz	Fastqsanger.gz
	SRR28349256_2.fastq.gz	Fastqsanger.gz
	SRR28349257_1.fastq.gz	Fastqsanger.gz
	SRR28349257_2.fastq.gz	Fastqsanger.gz
	SRR28349258_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

RNA-seq data from Giardia intestinalis WB trohozoites 7h into encysting Giardia cells infecting human Caco-2 cells

Project description:RNA-seq data from Giardia intestinalis WB trohozoites 7h into encysting Giardia cells infecting human Caco-2 cells

2022-01-31 | GSE144001 | GEO

RNA-seq data from Giardia intestinalis WB trohozoites infecting human Caco-2 cells

Project description:RNA-seq data from Giardia intestinalis WB trohozoites infecting human Caco-2 cells

2020-02-20 | GSE144004 | GEO

Analysis of the Transcriptomes of Giardia intestinalis Assemblages A, B and E Using Strand-specific RNA-seq

Project description:We have performed strand-specific RNA-seq of trophozoites from four different Giardia intestinalis strains (A=WB and AS175, B=GS, E=P15). Comparison of mRNA levels in four different Giardia intestinalis strains.

2013-03-28 | E-GEOD-36490 | biostudies-arrayexpress

RNA-seq data from Giardia intestinalis WB trohozoites infecting human Caco-2 cells

Project description:RNA-seq data from Giardia intestinalis WB trohozoites infecting human Caco-2 cells

| PRJNA602491 | ENA

RNA-seq data from Giardia intestinalis WB trohozoites 7h into encysting Giardia cells infecting human Caco-2 cells

Project description:RNA-seq data from Giardia intestinalis WB trohozoites 7h into encysting Giardia cells infecting human Caco-2 cells

| PRJNA602486 | ENA

RNA-seq data from human Caco-2 cells co-incubated with Giardia intestinalis WB cyst cells

Project description:RNA-seq data from human Caco-2 cells co-incubated with Giardia intestinalis WB cyst cells

| PRJNA722440 | ENA

Analysis of the Transcriptomes of Giardia intestinalis Assemblages A, B and E Using Strand-specific RNA-seq

Project description:We have performed strand-specific RNA-seq of trophozoites from four different Giardia intestinalis strains (A=WB and AS175, B=GS, E=P15).

2013-03-28 | GSE36490 | GEO

RNA-seq data of human enteroid- Giardia intestinalis infection

Project description:To investigate the transcriptional responses of intestinal epithelial cells and Giardia intestinalis, assemblage A isolate WB-C6, trophozoites during infection, we infected human enteroids with preconditioned trophozoites for 1h and 3h. Giardia intestinalis trophozoites were preconditioned before the infection with either DMEM/F-12 or DMEM/F-12 supplemented with 10% FBS to modify the trophozoites’ fitness.

2023-04-24 | GSE220954 | GEO

Project description:RNA sequencing of Giardia duodenalis-treated Caco-2 cells

| PRJNA601080 | ENA

Peptidylarginine Deiminase inhibition abolishes the production of large extracellular vesicles from Giardia intestinalis, affecting host-pathogen interactions by hindering adhesion to host cells

Project description:Giardia intestinalis is a microaerophilic protozoan that is an important etiologic agent of diarrhea worldwide. There is evidence that under diverse conditions, the parasite is capable of shedding extracellular vesicles (EVs) which modulate the physiopathology of giardiasis. Here we describe new features of G. intestinalis EV production, revealing its capacity to shed two different enriched EV populations (large (LEV) and small extracellular vesicles (SEV)) and identified relevant adhesion functions associated with the larger population. Proteomic analysis revealed differences in proteins relevant for virulence and host-pathogen interactions between the two EV subsets. We assessed the effect of two recently identified inhibitors of EV release in mammalian cells, namely peptidylarginine deiminase (PAD) inhibitor and cannabidiol (CBD), on EV release from Giardia and their putative effects on host-pathogen interactions. PAD-inhibitor Cl-amidine and CBD were both able to effectively reduce EV shedding, the PAD-inhibitor specifically affecting the release of LEVs and reducing parasite attachment to host cells in vitro. The strong efficacy of the PAD-inhibitor on Giardia EV release indicates a phylogenetically conserved pathway of PAD-mediated EV release, most likely affecting the Giardia arginine deiminase (GiADI) homolog of mammalian PADs. Our results suggest that LEVs and SEVs are differently involved in protozoa communication, and that treatment with EV-inhibitors may be a novel strategy for recurrent giardiasis treatment.

2020-09-21 | PXD018460 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data