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Ribosome profiling analysis of neuroblastoma cells in response to amidino-rocaglate treatment

ABSTRACT: Ribosome profiling analysis of neuroblastoma cells in response to amidino-rocaglate treatment

PROVIDER: PRJNA1088608 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28361540_1.fastq.gz	Fastqsanger.gz
	SRR28361540_2.fastq.gz	Fastqsanger.gz
	SRR28361541_1.fastq.gz	Fastqsanger.gz
	SRR28361541_2.fastq.gz	Fastqsanger.gz
	SRR28361542_1.fastq.gz	Fastqsanger.gz

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Ribosome profiling analysis of neuroblastoma cells in response to amidino-rocaglate treatment

Project description:MYCN-amplified neuroblastoma cells exhibit upregulation of translation regulation factors and ribosome biogenesis proteins as a result of MYCN-driven transcriptional amplification. Here, we treated MYCN-amplified and non-amplified neuroblastoma cells with a novel translation inhibitor, amidino-rocaglate CMLD12824, to compare the defects in translational efficiency.

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Project description:PAR-CLIP analysis of neuroblastoma cells in response to amidino-rocaglate treatment

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