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FIGHT-207- Anonymized Genomic Alterations and Clinical Responses

ABSTRACT: FIGHT-207- Anonymized Genomic Alterations and Clinical Responses

PROVIDER: PRJNA1089711 | ENA |

REPOSITORIES: ENA

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NK cells derived exosomes carry miR-207 and alleviate depression-like symptoms in mice

Project description:MicroRNAs (miRNAs) are 20–24 nt RNAs that can be packaged into exosomes and play important regulatory roles. Here we show that miRNA-containing exosomes from NK cells could alleviate symptoms of chronic mild stress in mice. In vivo experiment, these exosomes decreased the levels of pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α in the medium of astrocytes. By microarray analysis of exosome miRNA profiles, miR-207 was found to be an overexpressed miRNA in exosomes derived from unstressed mice. Experiments confirmed that miR-207 directly targets TLR4 interactor with leucine-rich repeats (Tril) and inhibits NF-κB signaling downsream of TLRs in astrocytes. When overexpressed in astrocytes, miR-207 decreased the release of pro-inflammatory cytokines and by inclusion of miR-207 inhibitor in astrocytes, higher release of pro-inflammatory cytokines and higher expression of Tril was found in vitro experiments. When NK cells were transfected with miR-207 inhibitor, miR-207 levels in NK cells derived exosomes were also declined. These exosomes with low miR-207 levels showed a decreased antidepressant activity in the vivo experiment. Collectively, our findings revealed that exosomal miR-207 alleviated the depression symptoms of stress mice by targeting Tril to inhibit NF-κB signaling downstream of TLRs in astrocytes.

2019-10-30 | GSE139551 | GEO

Pemigatinib in previously treated solid tumors with activating FGFR1-FGFR3 alterations: phase 2 FIGHT-207 basket trial.

Project description:Fibroblast growth factor receptor (FGFR) alterations drive oncogenesis in multiple tumor types. Here we studied pemigatinib, a selective, potent, oral FGFR1-FGFR3 inhibitor, in the phase 2 FIGHT-207 basket study of FGFR-altered advanced solid tumors. Primary end points were objective response rate (ORR) in cohorts A (fusions/rearrangements, n = 49) and B (activating non-kinase domain mutations, n = 32). Secondary end points were progression-free survival, duration of response and overall survival in cohorts A and B, and safety. Exploratory end points included ORR of cohort C (kinase domain mutations, potentially pathogenic variants of unknown significance, n = 26) and analysis of co-alterations associated with resistance and response. ORRs for cohorts A, B and C were 26.5% (13/49), 9.4% (3/32) and 3.8% (1/26), respectively. Tumors with no approved FGFR inhibitors or those with alterations not previously confirmed to be sensitive to FGFR inhibition had objective responses. In cohorts A and B, the median progression-free survival was 4.5 and 3.7 months, median duration of response was 7.8 and 6.9 months and median overall survival was 17.5 and 11.4 months, respectively. Safety was consistent with previous reports. The most common any-grade treatment-emergent adverse events were hyperphosphatemia (84%) and stomatitis (53%). TP53 co-mutations were associated with lack of response and BAP1 alterations with higher response rates. FGFR1-FGFR3 gatekeeper and molecular brake mutations led to acquired resistance. New therapeutic areas for FGFR inhibition and drug failure mechanisms were identified across tumor types. ClinicalTrials.gov identifier: NCT03822117 .

| S-EPMC11186762 | biostudies-literature

Emiliania huxleyi virus 207

Project description:Emiliania huxleyi virus 207 genome sequencing project

| PRJNA47657 | ENA

Panicum virgatum cultivar:SPR-207

Project description:Panicum virgatum exome capture - SPR-207

| PRJNA447861 | ENA

Sinorhizobium fredii strain:USDA 207

Project description:Sinorhizobium fredii USDA 207 genome sequencing

| PRJNA1115694 | ENA

Overexpression of TMEM213, 207, 116, 72 and 30B in HEK293 cell line

Project description:TMEM213, 207, 116, 72 and 30B were found to be deregulated in ccRCC tumors, but their function in the epithelium remains unclear. To obtain an insight into their role in cellular processes the five TMEM genes were overexpressed in HEK293 cell line

2023-08-18 | GSE222973 | GEO

Populus trichocarpa cultivar:207

Project description:Populus trichocarpa 207 Gene Expression Profiling - 207_N_1_22_14 transcriptome

| PRJNA580787 | ENA

Populus trichocarpa cultivar:207

Project description:Populus trichocarpa 207 Gene Expression Profiling - 207_N_2_20_49 transcriptome

| PRJNA712242 | ENA

Populus trichocarpa cultivar:207

Project description:Populus trichocarpa 207 Gene Expression Profiling - 207_S_3_8_36 transcriptome

| PRJNA654162 | ENA

Populus trichocarpa cultivar:207

Project description:Populus trichocarpa 207 Gene Expression Profiling - 207_S_4_24_26 transcriptome