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Maternal Stress During Pregnancy Imprints Fetal Lung Group 2 Innate Lymphoid Cells

ABSTRACT: Maternal Stress During Pregnancy Imprints Fetal Lung Group 2 Innate Lymphoid Cells

PROVIDER: PRJNA1093050 | ENA |

REPOSITORIES: ENA

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Maternal Asthma During Pregnancy Imprints Fetal Lung Group 2 Innate Lymphoid Cells [snRNA-Seq]

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Maternal Asthma During Pregnancy Imprints Histone Modification of Lung Group 2 Innate Lymphoid Cells

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Maternal Stress During Pregnancy Imprints Fetal Lung Group 2 Innate Lymphoid Cells

Project description:We investigated the gene expression on the feral lungs (E18) in the offspring of dexamethasone (DEX)- or PBS- treated mothers by single cell RNA sequence.

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Maternal Asthma During Pregnancy Imprints Fetal Lung Group 2 Innate Lymphoid Cells [snRNA-Seq]

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RNA-Seq of Group 2 innate lymphoid cells (ILC2) from uterine tissue (Virgin, E9.5, E18.5)

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Transcriptional and Functional Programming of Decidual Innate Lymphoid Cells

Project description:A successful pregnancy requires many physiological adaptations from the mother, including the establishment of tolerance towards the semiallogeneic fetus. Innate lymphoid cells (ILCs) have arisen as important players in immune regulation and tissue homeostasis at mucosal and barrier surfaces. Dimensionality reduction and transcriptomic analysis revealed the presence of two novel CD56Bright decidual ILCs, C10 and C2, that express divergent levels of Eomes. We found that decidual C10, C2, and cNKs correlated highly with previously identified first trimester decidual dNKs (dNK1-3). Functional analysis revealed polyfunctional profiles that depend on the nature of the stimulus, with a preference for IFNgamma and VEGF production. Overall, our data suggests persistence of pregnancy-specific decidual innate lymphocytes across pregnancy.

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microRNA expression in innate lymphoid cells from human decidua

Project description:Innate lymphoid cells are a heterogeneous subset of lymphocytes deeply implicated in the innate immune responses to different pathogens, in lymphoid organogenesis and in the maintenance of tissue homeostasis. Group 3 innate lymphoid cells (ILC3) have been detected in human decidua, where they play a role in the early inflammatory phase favoring implantation and tissue remodeling as well as in the subsequent regulatory phase preventing fetal rejection and supporting neoangiogenesis. A balance between inflammation and immune tolerance is required to maintain pregnancy, thus maternal immune system must be controlled by finely tuned mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs with important regulatory roles in immune cells, but their function in decidual ILC3 (dILC3) and decidual NK (dNK) cells is still undefined. Here, we examined the miRNome by microarray in these cells during the first trimester of pregnancy and compared with miRNA profiles of peripheral blood NK (pbNK) cells from pregnant women. We show that distinct miRNA profiles could clearly distinguish dILC3 from NK cells. Correlation analyses revealed that dNK and pbNK miRNome profiles are more similar to each other as compared to dILC3. Overall, our data identified specific miRNA signatures distinguishing dILC3, dNK and pbNK cells.

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