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ABSTRACT: To explore microbial natural product

PROVIDER: PRJNA1093170 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28492323_1.fastq.gz	Fastqsanger.gz
	SRR28492324_1.fastq.gz	Fastqsanger.gz
	SRR28492324_2.fastq.gz	Fastqsanger.gz

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LAESI-MS for natural products discovery

Project description:LAESI-MS data were collected for high-throughput microbial natural product discovery. Bacteria were cultivated with chemical elicitors and the crude extracts were analyzed by LAESI-MS in a high-throughput manner.

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The microbial functional structure along an elevation gradient of the Shennongjia Mountain as characterized by GeoChip

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The microbial functional structure along an elevation gradient of the Shennongjia Mountain as characterized by GeoChip

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Project description:Natural product rich actinomycete genome sequencing

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Minimizing Taxonomic and Natural Product Redundancy in Microbial Libraries Using MALDI-TOF MS and the Bioinformatics Pipeline IDBac

Project description:This bacterial MALDI-TOF dataset was used for the study "AMinimizing Taxonomic and Natural Product Redundancy in Microbial Libraries Using MALDI-TOF MS and the Bioinformatics Pipeline IDBac" It consists of triplicate MALDI-TOF MS profiles (both reflectron and linear datasets) for >1,600 bacteria cultivated from a collection in Iceland.

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Erianin abrogates vasculogenic mimicry through targeting m5C methylase NSUN2

Project description:Purpose: The precise temporal and spatial regulation of N5-methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism. Targeting m5C regulation in cancer cells may be a potential strategy for cancer therapy. Erianin is a natural product isolated from Dendrobium chrysotoxum Lindl. Howbeit, the in‐depth understanding of interaction between erianin and m5C modification remains indistinct. Methods: Natural product library screening was used to explore the effects of natural product monomers on uveal melanoma (UM) cells. Intraocular xenografts model was established to examine the effect of erianin. Immunoprecipitation mass spectrometry (IP-MS) and molecular docking analyses were performed to identify NSUN2 as the target of erianin. m5C-meRIP-seq and m5C-meRIP-qPCR analyses were performed to identify the functional target of NSUN2. Tube formation assay and CD31-PAS double staining were used to detect vasculogenic mimicry (VM) in UM. Results: Herein, we report the discovery of erianin as an effective inhibitor of uveal melanoma. Mechanistically, the targeted inhibition of NSUN2 function by erianin results in a decrease in the m5C modification and expression levels of CHAC1 in UM, thereby curtailing the formation of VM. Conclusions: Collectively, our data suggested that erianin significantly inhibited UM progression in vitro and in vivo. Our study unveils a novel therapeutic strategy for combating UM.

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