Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Systemic comparison of molecular characteristics in different skin fibroblast senescent models

ABSTRACT: Systemic comparison of molecular characteristics in different skin fibroblast senescent models

PROVIDER: PRJNA1094942 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28516348_1.fastq.gz	Fastqsanger.gz
	SRR28516348_2.fastq.gz	Fastqsanger.gz
	SRR28516349_1.fastq.gz	Fastqsanger.gz
	SRR28516349_2.fastq.gz	Fastqsanger.gz
	SRR28516350_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Systemic comparison of molecular characteristics in different skin fibroblast senescent models

Project description:Each senescent FB model exhibited different characteristics. Besides the upregulated expression of natural senescence features, FB-UVB and FB-ATV expressed high levels of senescence-related genes including SASP, and FB-P30 had the greatest similarity with FB-E. However, D-galactose-stimulated FB did not clearly present aging characteristics. It provides references for choosing senescent FB model in studying aging and related skin disease.

2024-04-10 | GSE262932 | GEO

Microarray analysis in senescent chicken embryo fibroblast

Project description:Transcriptional profiling of healthy chicken embryo fibroblast (CEF, P4) cells comparing senescent chicken embryo fibroblast (CEF, P18) cells. Goal was to identify differentially expressed genes comparing between healthy (P4) and senescent (P18) CEF cells. Two-condition experiment, healthy CEF (P4) vs. senescence CEF (P18). Biological replicates: 1 control CEF (P4) sample, 1 CEF (P18) experimental sample.

2011-05-12 | E-GEOD-29258 | biostudies-arrayexpress

Microarray analysis in senescent chicken embryo fibroblast

2011-05-12 | GSE29258 | GEO

Nascent proteome analysis of proliferating and senescent BJ fibroblast treated with GC7

Project description:Analysis of proteomic changes in proliferating and senescent BJ fibroblast treated with eIF5A hypusination inhibitor GC7 for 12h.

2024-07-12 | PXD034334 | Pride

Next Generation Sequencing of Total RNA of Senescent WI38 Human Fibroblast with and without knockdown of G3BP1

Project description:Next Generation Sequencing of Total RNA of Senescent WI38 Human Fibroblast with and without knockdown of G3BP1

2020-06-04 | GSE151745 | GEO

High-throughput sequencing of AGO-immunoprecipitating miRs in human senescent fibroblast WI-38

Project description:In humans, there are four Ago proteins (Ago1M-bM-^@M-^S4) and AGO1- and 2 were previously implicated in TGS induced by exogenous siRNAs and microRNAs (miRs) directed against gene promoter transcripts via promotion of changes in histone covalent modifications and DNA methylation. Not-with-standing, many mechanistic details of this process remain poorly defined in human cells, and very little is known about the identity of possible endogenous signals, which may drive this process in human cells. Given the evolutionary conserved role of siRNAs and AGO proteins in TGS and heterochromatin formation, we set out to analyse their possible involvement in senesence-associated repression of E2F target genes. To obtain a detailed picture of AGO-immunoprecipitating miRs (RIP) in senescent cells, we used next-generation sequencing (NGS)(RIP-Seq). We also included histone H3 dimethylated on lysine 9 (H3K9me2) in this analysis to assign potential AGO2-interacting miRs to a repressive chromatin state and unfractionated, cellular RNA from senescent cells for normalisation. Determination of AGO AGO-immunoprecipitating miRs in WI-38 senescent human fibroblast

2011-12-17 | E-GEOD-34494 | biostudies-arrayexpress

Senescent Characteristics of Human Corneal Endothelial Cells upon Ultraviolet-A Exposure

Project description:Senescent Characteristics of Human Corneal Endothelial Cells upon Ultraviolet-A Exposure

| PRJNA1052700 | ENA

Clearance of a senescent macrophage-enriched niche ameliorates tumorigenesis in KRAS-driven murine lung cancer models

Project description:Understanding the important role of the tumour microenvironment on tumour initiation and progression is vital for a comprehensive understanding of cancer biology to design effective treatment strategies. Cellular senescence, while traditionally thought of as a cell autonomous tumour-suppressive response to potentially oncogenic insults, is now appreciated to have paracrine tumour promoting roles. We demonstrate a pro-tumourigenic effect of senescent microenvironmental cells on mouse lung tumour progression. To better understand the characteristics of these pro-tumourigenic senescent cells in the tumour microenvironment, we compare putatively senescent cells (reported by mCherry-expression) and non-senescent cells (mCherry-negative cells) from the lung microenvironment of mice induced to form lung tumours by oncogenic KrasG12D-expression in the lung epithelium. Putatively senescent cells are isolated by FACS, based on mCherry-expression which is expressed under the control of the Cdkn2a (p16) locus using a novel genetically engineered allele (p16FDR/+), along with their non-senescent counterparts for comparison by single cell RNA-sequencing.

2023-06-14 | GSE203447 | GEO

Characterizing senescent lung epithelial cells

Project description:We characterized senescent alveolar epithelial cells in an effort to better understand how these cells contribute to lung remodeling and fibrosis. The transcriptional profiles of several different types of senescent lung epithelial cells was evaluated using various induction methods in order to better understand core characteristics associated with the senescent program in epithelial cells of the lung.

2021-03-08 | GSE166034 | GEO

Myofibroblast transcriptome indicates SFRP2+ fibroblast progenitors in systemic sclerosis skin

Project description:Myofibroblast transcriptome indicates SFRP2+ fibroblast progenitors in systemic sclerosis skin

| PRJNA576702 | ENA