Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Comparative Genomics of Methicillin-Resistant Non-aureus Staphylococci Isolated from Universiti Malaysia Kelantan Farms

PROVIDER: PRJNA1095671 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR28537346_1.fastq.gz	Fastqsanger.gz
	SRR28920438_1.fastq.gz	Fastqsanger.gz
	SRR28921391_1.fastq.gz	Fastqsanger.gz
	SRR29014007_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 7

Similar Datasets

Project description:Comparative Genomics of Methicillin-Resistant Non-aureus Staphylococci Isolated from cattle in Bachok, Kelantan, Malaysia

| PRJNA1111259 | ENA

Project description:Comparative Genomics of Methicillin-Resistant Non-aureus Staphylococci Isolated from Cattle in Kuala Lipis, Pahang, Malaysia

| PRJNA1109545 | ENA

Potential Mechanism of Action of 3'-Demethoxy-6-O-Demethylisoguaiacin on Methicillin-resistant Staphylococcus aureus

2015-06-27 | GSE70309 | GEO

Staphylococcus aureus

Project description:Comparative genomics of methicillin-resistant Staphylococcus aureus (MRSA)

| PRJDB3046 | ENA

Project description:Livestock-associated methicillin-resistant Staphylococcus aureus isolated in Hungarian pig farms

| PRJNA901421 | ENA

Potential Mechanism of Action of 3'-Demethoxy-6-O-Demethylisoguaiacin on Methicillin-resistant Staphylococcus aureus

Project description:Methicillin-resistant Staphylococcus aureus is one of the major causative agents associated to infections with a high morbidity and mortality in hospitals worldwide. In previous studies, we reported that lignan 3'-demethoxy-6-O-demethylisoguaiacin isolated and characterized from Larrea tridentata showed the best activity towards methicillin-resistant S. aureus. Understanding of mechanism of action of drugs allows design drugs in a better way. Therefore, we employed microarray to obtain gene expression profile of methicillin-resistant S. aureus after exposure to 3'-demethoxy-6-O-demethylisoguaiacin. The results showed that lignan had an effect on cell membrane affecting proteins of the ATP-binding cassette (ABC) transport system causing bacteria death. This study consisted of comparison of isolated RNA of MRSA not treated and MRSA treated with lignan 3'-demethoxy-6-O-demethylisoguaiacin. Both RNAs samples were differentially dyed with Cy3 and Cy5 during cDNA synthesis and hybridized on DNA chip. Afterwards, the chip was scanned in a GenePix 4000B scanner. The resulting gene expression profile was analyzed in databases for functional annotations to find a potential mechanism of the lignan in MRSA.

2015-06-27 | E-GEOD-70309 | biostudies-arrayexpress

Evolution of hypervirulence during bloodstream adaptation of CA-MRSA strain USA300

Project description:The epidemic community-acquired methicillin-resistant S. aureus (CA-MRSA) clone USA300 has recently become a leading cause of hospital-associated bloodstream infections (BSI). Leveraging this recent introduction into hospitals and the limited genetic variation across the USA300 strains, we combined microbial comparative genomics with phenotypic analyses to discover adaptive mutations. USA300 isolates from BSI were found to have independently evolved single nucleotide variants in the transcriptional regulator sarZ. sarZ inactivation lead to altered expression of virulence factors, resulting in increased lethality in a murine model of BSI. Thus, USA300 strains can optimize their fitness in hospitals through evolution of higher virulence.

2022-10-08 | GSE185544 | GEO

Proteomic differences in methicillin-sensitive and methicillin-resistant Staphylococcus aureus

Project description:To establish general differences between the protein expression in S. aureus strains, five methicillin sensitive S. aureus (MSSA) strains and five methicillin resistant S. aureus (MRSA) strains were compared both individually and as MSSA and MRSA groups in the absence of antibiotics. Proteins were compared by ultra-performance liquid chromatography-mass spectrometry.

2023-04-25 | PXD021629 | Pride

Project description:linezolid- and methicillin-resistant coagulase-negative staphylococci

| PRJNA1077915 | ENA

Staphylococcus

Project description:Surveillance of methicillin resistant Staphylococci from Egypt

| PRJNA964454 | ENA