Project description:Conjugative plasmids, major vehicles for the spread of antibiotic resistance genes, often contain multiple toxin‒antitoxin (TA) systems. However, the physiological functions of TA systems remain obscure. By studying TA families commonly found on colistin-resistant IncI2 mcr-1-bearing plasmids, we discovered that the HicAB TA, acts as a crucial addiction module to increase horizontal plasmid‒plasmid competition.
Project description:mcr-1-positive colistin-resistant Escherichia coli strains isolated from international airplane waste, and wastewater treatment plants
Project description:Identification of mobile colistin resistance genes (mcr-1.1, mcr-5, mcr-8.1) in Enterobacteriaceae of human and animal origins, Nigeria.
