Project description:Conjugative plasmids, major vehicles for the spread of antibiotic resistance genes, often contain multiple toxin‒antitoxin (TA) systems. However, the physiological functions of TA systems remain obscure. By studying TA families commonly found on colistin-resistant IncI2 mcr-1-bearing plasmids, we discovered that the HicAB TA, acts as a crucial addiction module to increase horizontal plasmid‒plasmid competition.
Project description:mcr-1-positive colistin-resistant Escherichia coli strains isolated from international airplane waste, and wastewater treatment plants
Project description:Mobile colistin resistance (mcr) gene prevalence and molecular characterization of mcr and extended-spectrum beta-lactamase (ESBL) genes containing mobile genetic elements
