Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The temporal progression of lung immune remodeling during breast cancer metastasis

ABSTRACT: The temporal progression of lung immune remodeling during breast cancer metastasis

PROVIDER: PRJNA1100478 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28702600.fastq.gz	Fastqsanger.gz
	SRR28702601.fastq.gz	Fastqsanger.gz
	SRR28702602.fastq.gz	Fastqsanger.gz
	SRR28702603.fastq.gz	Fastqsanger.gz
	SRR28702604.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 108

Similar Datasets

Methylome remodeling in regional breast cancer metastasis

Project description:Methylome remodeling in regional breast cancer metastasis

| PRJNA254073 | ENA

The temporal progression of lung immune remodeling during breast cancer metastasis

Project description:The dynamics of immune reprogramming in the breast cancer lung metastastic niche remains incomplete. We used MULTI-seq (McGinnis, Patterson, et al., Nature Methods, 2019) to perform multiplexed single-cell RNA-sequencing analysis of cryopreserved lung immune cells isolated from PyMT mice, freshly-isolated lung immune cells isolated from PyMT mice, and cryopreserved lung immune cells isolated from 4T1 tumor-bearing mice from the onset of primary tumorigenesis through the formation of macrometastatic lesions. Cryopreserved PyMT samples were collected from 6-14 weeks of age, fresh PyMT samples were collected at 6, 10 and 13 weeks of age (with age-matched wild-type controls)

2024-04-22 | GSE263963 | GEO

Methylome remodeling in regional breast cancer metastasis [expression]

Project description:We sought to characterize methylome remodeling during regional metastasis. We profiled the DNA methylome (n=44) and transcriptome (n=36) of matched primary breast tumors and regional metastases.

2014-12-01 | GSE57968 | GEO

Methylome remodeling in regional breast cancer metastasis [DNA methylation]

Project description:Genome-wide DNA methylation profiling of of 44 matched primary breast tumors and metastases. We sought to characterize methylome remodeling during regional metastasis. We profiled the DNA methylome (n=44) and transcriptome (n=36) of matched primary breast tumors and regional metastases.

2014-12-01 | GSE58999 | GEO

Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression

Project description:Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression

| PRJNA393323 | ENA

Therapeutic targeting ERRγ suppresses metastasis via extracellular matrix remodeling in small cell lung cancer (ChIP-Seq)

Project description:Small-cell lung cancer (SCLC) is the most aggressive and lethal type of lung cancer, characterized by limited treatment options, early and frequent metastasis. However, the determinants of metastasis in SCLC are poorly defined. Here, we show that estrogen-related receptor gamma (ERRγ) is overexpressed in metastatic SCLC tumors, and it is positively associated with SCLC progression. ERRγ functions as an essential activator of ECM remodeling and cell adhesion, two critical steps in metastasis, by directly regulating the expression of major genes involved in these processes. Genetic and pharmacological inhibition of ERRγ markedly reduces collagen production, cell-matrix adhesion, microfilaments production, and eventually blocks SCLC cell invasion and tumor metastasis. Notably, ERRγ antagonists significantly suppress tumor growth and metastasis and restore resistant SCLC vulnerability to chemotherapy in multiple cell-derived and patient-derived xenograft models. Taken together, these findings establish ERRγ as an attractive target for metastatic SCLC and provide a potential pharmacological strategy for treating this lethal disease.

2024-05-15 | GSE259272 | GEO

Therapeutic targeting ERRγ suppresses metastasis via extracellular matrix remodeling in small cell lung cancer (RNA-Seq)

2024-05-15 | GSE259271 | GEO

Temporal and Clonal Progression in Pediatric Ependymoma

Project description:Temporal and Clonal Progression in Pediatric Ependymoma

| PRJNA408012 | ENA

Temporal and Clonal Progression in Pediatric Ependymoma

Project description:Temporal and Clonal Progression in Pediatric Ependymoma

| PRJNA408011 | ENA

Lung metastasis of breast cancer

Project description:Lung metastasis of breast cancer

| PRJNA499112 | ENA