Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Hypoxia-mediated high expression of TRIM15 promotes malignant progression of high-grade serous ovarian cancer (HGSOC) through activation of AKT signaling pathway by K63 ubiquitination

ABSTRACT: Hypoxia-mediated high expression of TRIM15 promotes malignant progression of high-grade serous ovarian cancer (HGSOC) through activation of AKT signaling pathway by K63 ubiquitination

PROVIDER: PRJNA1101851 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Hypoxia-mediated high expression of TRIM15 promotes malignant progression of high-grade serous ovarian cancer (HGSOC) through activation of AKT signaling pathway by K63 ubiquitination

Project description:To analyze the gene expression patterns of ovary in 4 patients with high-grade serous ovarian cancer (HGSOC) and 4 normal individuals.

2025-01-06 | GSE264282 | GEO

Gene expression in High-Grade Serous Ovarian Cancer (HGSOC) cells

Project description:Gene expression in High-Grade Serous Ovarian Cancer (HGSOC) cells

2024-12-31 | GSE214904 | GEO

Single-cell RNA sequencing samples from high-grade serous ovarian cancer (HGSOC)

Project description:We measured gene expression in single-cell RNA sequencing samples from patients with high-grade serous ovarian cancer (HGSOC), for a study on improving HGSOC subtype definition by taking into account varying cell type proportions within tumors.

2020-10-03 | GSE158937 | GEO

Gene expression in High-Grade Serous Ovarian Cancer (HGSOC) cells

Project description:Gene expression in High-Grade Serous Ovarian Cancer (HGSOC) cells

| PRJNA887714 | ENA

microRNA profiling of serum microRNA from high grade serous ovarian carcinoma

Project description:High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic neoplasm, with five-year survival rate below 30%. Early disease detection is of utmost importance to improve the cure rate of HGSOC. Liquid biopsies are now becoming a new paradigm to develop novel biomarkers with diagnostic and prognostic purposes. The focus of this study was to detect the levels of circulating miRNAs in tissues and sera from patients with HGSOC and to evaluate their diagnostic value. To this end, an array-based discovery platform, followed by an innovative statistical approach of data normalization, was exploited, to identify miRNA species selectively expressed in serum of patients with HGSOC. Sera from 106 high grade serous ovarian carcinoma (HGSOC) and 24 healthy controls were used for profiling serum microRNA using a modified version of a commercially available microarray, with the aim of identifying differentially expressed microRNA between tumor patients and healthy controls.

2017-01-30 | E-MTAB-4667 | biostudies-arrayexpress

Evolution of core archetypal phenotypes in high-grade serous ovarian cancer (HGSOC)

Project description:Evolution of core archetypal phenotypes in high-grade serous ovarian cancer (HGSOC)

| PRJNA666354 | ENA

Single-cell RNA sequencing samples from high-grade serous ovarian cancer (HGSOC)

Project description:Single-cell RNA sequencing samples from high-grade serous ovarian cancer (HGSOC)

| PRJNA667060 | ENA

E3 ubiquitin ligase DTX2 reinforces innate antiviral immune responses by modulating K63-linked ubiquitination of TBK1

Project description:TBK1 plays a pivotal role in innate antiviral immunity, serving as a critical mediator downstream of various pattern recognition receptors (PRRs). TBK1 activity is tightly regulated by post-translational modifications (PTMs) including ubiquitination to maintain innate immune homeostasis. Here, we identify the Deltex E3 ubiquitin ligase 2 (DTX2) as a positive regulator of innate antiviral signaling in response to RNA viruses. We find that DTX2 overexpression enhances antiviral signaling, whereas loss of DTX2 evidently reduces antiviral responses. Mechanistically, we demonstrated that DTX2 directly interacts with TBK1 and promotes TBK1 K63-linked polyubiquitination to regulate antiviral signaling. Collectively, our study reveals that DTX2 plays a novel positive regulatory role in antiviral signaling by modulating the K63-linked ubiquitination of TBK1 to maintain the balance of innate antiviral immune responses.

2025-01-04 | GSE285743 | GEO

Evaluation of Tumor Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer

Project description:Tumor infiltrating lymphocytes (TILs) play a significant role in the tumor microenvironment in high-grade serous ovarian cancer (HGSOC). To better understand the interactions and functions of TILs in HGSOC progression, we performed proteogenomic profiling of TILs in 65 tumors collected from 12 HGSOC patients.

2024-03-15 | PXD045710 | Pride

LncRNA and mRNA expression profiles in High-grade serous ovarian cancer, Low-grade serous ovarian cancer and Normal fallopian tube

Project description:Ovarian cancer is the most lethal gynecologic cancer. High-grade serous ovarian carcinoma (HGSOC) is the most common histologic subtype, accounting for three quarters of ovarian cancer. To clarify the changes of gene expression in serous ovarian cancer, we performed lncRNA and mRNA microarrays to identify differentially expressed lncRNAs and mRNAs in High-grade and Low-grade serous ovarian carcinoma compared with Normal fallopian tube.

2020-02-12 | GSE135886 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data