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UBXN3B Is Crucial for B Lymphopoiesis [scRNA-seq]

ABSTRACT: UBXN3B Is Crucial for B Lymphopoiesis [scRNA-seq]

PROVIDER: PRJNA1106177 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28841256_1.fastq.gz	Fastqsanger.gz
	SRR28841256_2.fastq.gz	Fastqsanger.gz
	SRR28841257_1.fastq.gz	Fastqsanger.gz
	SRR28841257_2.fastq.gz	Fastqsanger.gz

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UBXN3B Is Crucial for B Lymphopoiesis

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UBXN3B Is Crucial for B Lymphopoiesis [scRNA-seq]

Project description:Hematopoiesis is finely regulated to enable timely production of the right numbers and types of immune cells. Herein, we report the crucial function of UBXN3B in B lymphopoiesis. In the inducible global knockout and B cell-specific Ubxn3b knockout model, the terminal B cell number is reduced by > 90% in both Ubxn3b-/- mouse models. Transfer of wildtype bone marrows to irradiated global Ubxn3b-/- restores the B population, while reverse transplantation fails to do so. The deficiency begins from the precursor stage. The B population drops rapidly with significant apoptosis, presents a much higher level of pro-caspase-3 protein following induction of Ubxn3b knockout. RNA-sequencing reveals significantly suppressed cell cycle genes while upregulated TP53 signaling in Ubxn3b-/- B cells. Ubxn3b-/- mice are highly vulnerable to respiratory viruses, with increased lung viral loads and immunopathology, reduced B population and virus-specific IgM/IgG. This study reveals a cell-intrinsic essential role of UBXN3B in B cell survival and UBXN3B as a potential therapeutic target for B-cell related diseases.

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