Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (10HDA)

ABSTRACT: Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (10HDA)

PROVIDER: PRJNA1106911 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28867741.fastq.gz	Fastqsanger.gz
	SRR28867742.fastq.gz	Fastqsanger.gz
	SRR28867743.fastq.gz	Fastqsanger.gz
	SRR28867744.fastq.gz	Fastqsanger.gz
	SRR28867745.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (BPA)

Project description:Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (BPA)

| PRJNA1106913 | ENA

Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (BPA)

Project description:Pregannt Cyp19-EGFP mice (maintained on a soybean free mouse chow diet) were treated with either 50μg/kg/day Bsiphenol A or vehicle (ethinol in peanut oil) between gestational days (GD) 10.5-14.5. On GD15.5, fetuses were dissected and sex determined by SRY genotyping. Fetuses were obtained from different dams.

2024-05-08 | GSE266401 | GEO

Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (10HDA)

Project description:Primary cortical neurons were obtained from male Cyp19-EGFP mouse embryos at gestational day 15.5. Embryos were genotyped for SRY to determine sex, and only male embryos were used. Cells were seeded in 24-well plates containing 12 mm glass coverslips, coated with 100 µg/mL poly D-lysine to a density of ~0.45 x 106 cells/well and incubated in a humidified CO2 incubator (5% CO2, 37°C). Primary cortical from Cyp19-EGFP mouse embryos were obtained on GD 15.5. Neuronal cell cultures were treated with vehicle or 1mM 10HDA (Matreya, PA ,USA)

2024-05-14 | GSE266400 | GEO

Identification of differentially expressed genes in BPA-/- and BPA+/+ mouse melanomas.

Project description:Aim: Identify Ambra1-dependent regulation in melanoma development by comparing bulk RNA extracted from Ambra1-depleted (BPA-/-) mouse melanomas to Ambra1-wt (BPA+/+) melanomas.

2021-03-04 | GSE151134 | GEO

BPA impacts on HEK 293 cells

Project description:Bisphenol A (BPA) is an environmental endocrine disruptor which has been detected in almost all human bodies. Many studies have implied that BPA exposure is harmful to human health. Previous studies mainly focused on BPA effects on ER-positive cells. Genome-wide impact of BPA on gene regulation in ER-negative cells is unclear. In the present study, we performed RNA-seq to characterize BPA-induced gene regulation on ER-negative HEK 293 cells.

2014-10-10 | E-MTAB-1959 | biostudies-arrayexpress

Epigenetic profiling in adult brain after prenatal BPA exposure

Project description:Epigenetic profiling in adult brain after prenatal BPA exposure

| PRJNA1047014 | ENA

Epigenetic profiling in adult brain after prenatal BPA exposure [RRBS]

Project description:We reported that, in C57BL/6Slac mice, prenatally exposure to low-dose BPA induces up-regulation of genes associated with neuronal function and down-regulation of genes related to mitochondrial oxidative phosphorylation. Three-dimensional chromatin organization of these differential expressed genes revealed that up-regulated genes are primarily under control of remote enhancers, while down-regulated genes appear to be regulated by chromatin interactions among relative adjacent genes. Further examination of genome-wide repressive epigenetic modifications, specifically DNA methylation, H3K27me3, and H3K9me3 revealed that transcription of down-regulated genes might be repressed directly by enhanced DNA methylation and H3K27me3 modifications at promoter regions and indirectly by increased DNA methylation at their corresponding interaction regions, while up-regulated genes might be regulated by loss of H3K9me3 occupancy on distal regulatory regions.

2024-05-29 | GSE249013 | GEO

Epigenetic profiling in adult brain after prenatal BPA exposure [RNA-seq]

2024-05-29 | GSE249012 | GEO

Epigenetic profiling in adult brain after prenatal BPA exposure [ATAC-seq]

2024-05-29 | GSE249015 | GEO

Epigenetic profiling in adult brain after prenatal BPA exposure [ChIP-seq]

2024-05-29 | GSE249014 | GEO