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CoMtb alters the immune landscape following Mtb infection [B6 Sp140-/- scRNA-Seq]

ABSTRACT: CoMtb alters the immune landscape following Mtb infection [B6 Sp140-/- scRNA-Seq]

PROVIDER: PRJNA1107174 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28879712_1.fastq.gz	Fastqsanger.gz
	SRR28879712_2.fastq.gz	Fastqsanger.gz
	SRR28879713_1.fastq.gz	Fastqsanger.gz
	SRR28879713_2.fastq.gz	Fastqsanger.gz
	SRR28879714_1.fastq.gz	Fastqsanger.gz

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CoMtb alters the immune landscape following Mtb infection [B6 Sp140-/- scRNA-Seq]

Project description:To gain further insights into lesion development and effects of CoMtb on immune responses during infection. we performed single-cell RNA sequencing (scRNAseq) and flow cytometry analysis of lungs from Mtb-infected B6 Sp140-/- mice with and without CoMtb at 10 days after CD infection. We found that CoMtb induces rapid recruitment and activation of T cells. macrophage activation. and diminished late neutrophil responses.

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CoMtb alters the immune landscape following Mtb infection [B6 scSCRNAseq]

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CoMtb alters the immune landscape following Mtb infection [B6 scSCRNAseq]

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The antiviral nuclear body protein SP140 represses Ifnb1 transcript stabilization by the novel regulator RESIST [WT and SP140 KO RNA-seq]

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