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Construction of competing endogenous RNA networks in systemic lupus erythematosus by integrated analysis

ABSTRACT: Construction of competing endogenous RNA networks in systemic lupus erythematosus by integrated analysis

PROVIDER: PRJNA1108188 | ENA |

REPOSITORIES: ENA

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Construction of competing endogenous RNA networks in systemic lupus erythematosus by integrated analysis

Project description:SLE is a disease characterised by immune inflammation and damage to multiple organs. Recent investigations have linked competing endogenous RNAs (ceRNAs) to lupus. However, the exact mechanism through which the ceRNAs network affects SLE is still unclear. This study aims to investigate the regulatory functions of the ceRNAs network, which are important pathways that control the pathophysiological processes of SLE. We constructed a novel circRNA-miRNA-mRNA ceRNA network (HSA circ 0000345- HSA miR-22-3-P-ESR1/SIRT1) that may have a major impact on SLE.

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