Project description:MicroRNAs (miRNAs) are important regulators in the process of cardiac hypertrophy and heart failure. Previous studies showed that miR-199a is upregulated in pressure-overload cardiac hypertrophy and overexpression of miR-199a induces cardiac hypertrophy in vivo. However, the therapeutic role of anti-miR-199a treatment in cardiac hypertrophy is of little known. Here, we showed a novel and effective way to treat mice cardiac hypertrophy and restored cardiac function through injection of adeno-associated virus (AAV) which expressed anti-miR-199a tough decoys (TuDs). We performed the RNA-seq profiling in both AAV9-EGFP control and AAV9-anti-miR-199a TuDs injected cardiac hypertrophic mice. The transcriptome analysis indicates that genes related to cytoplasmic translation, mitochondrial respiratory chain complex assembly were upregulated by anti-miR-199a treated recovered hearts.

2020-12-31 | GSE155545 | GEO

adeno-associated virus 2

Project description:Adeno-associated virus type 2 transcriptome analysis by Illumina-based RNA sequencing (RNA-Seq)

| PRJNA322856 | ENA

Adeno-associated virus

Project description:Multiscale and cross-species evolution of adeno-associated viruses for kidney gene transfer

| PRJNA1154660 | ENA